Drug Identity
Active Ingredient
Naloxone
Drug Class
All Other Therapeutic Products, Antidotes
ATC Code
A06AH04, V03AB15
Status
Essential Medicine
What is Athiol?
Uses
Naloxone (HCl) is a semisynthetic opiate-receptor antagonist. Naloxone (HCl) is the N-allyl derivative of noroxymorphone. Classically, Na...
How It Works
To be administered by IV, IM or SC injection. The most rapid onset of action is achieved with IV use, which is recommended in emergency situations. Titrate the administration rate in accordance with the patients response. Dilute in NS or D5W solutions. The addition of 2 mg in 500 ml of either solution provides a concentration of 0.004 mg/ml.
How to Take It
1
Adult · IV,IM,SC
0.4 to 2 mg — As recommended.
Every 2 to 3 minutes
2
Child · Initial dose
10 ug/kg — As recommended.
3
Child · Intra Muscular
0.1 mg/kg — As recommended.
Every 2 to 3 minutes Or as required
4
Child · Intra Venous
0.1 mg/kg — As recommended.
Every 2 to 3 minutes Or as required
5
Child · Subcutaneous
0.1 mg/kg — As recommended.
Every 2 to 3 minutes Or as required
Important Warnings
Cardiovascular disease or those receiving cardiotoxic drugs (risk of serious adverse cardiovascular effects), maternal physical dependence on opioids (may precipitate withdrawal in newborn), pain, physical dependence on opioids (precipitates withdrawal), pregnancy except in labour, keep patient under observation as repeat doses may be needed
Side Effects
Agitationcardiac arrestheadachedizzinessdyspnoea (in children)hypertensionhyperventilationhypotensionnauseapulmonary oedematachycardiaventricular fibrillationvomitingarrhythmiabradycardia
Drug Interactions
Naloxone (HCl) is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholBuprenorphine (HCl)Clonidine (HCl)Dextromoramide (Tartrate)Dihydrocodeine (Tartrate)Dipipanone (HCl)EnfluraneLevorphanolMethadoneNalbuphine (HCl)OxymorphoneThis warning does not apply to the naloxone component in oral pentazocine/naloxone tablets. Naloxone injection is an antagonist that will reverse the actions of opiates. This reversal can occur when the opiate drug is being used clinically and when it is being abused. Physically dependent patients may experience withdrawal symptoms. Abrupt postoperative opioid reversal has resulted in hypotension
ventricular tachycardia and fibrillation
pulmonary edema
cardiac arrest
encephalopathy
and death. MajorPatients receiving naloxone injection should be monitored for changes in vital signs
nausea
Pregnancy & Lactation
Pregnancy
Use only if potential benefit outweighs risk.
Lactation
Avoid unless essential
Storage
Inj Store Below 40°C. Do not Freeze. Protect from Sunlight.
Price Intelligence
Rs 1,998.93
DRAP approved maximum price · per pack of 10 · approved 27 Jul, 2026
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 10Rs 1,998.93
Should you consider an alternative?
Other options containing Naloxone, and what they are not.
These contain this ingredient plus others. They are different medicines — do not swap.
Naloxo-X
0.4mg
Rs 190Rs 190/unit
Bajwa Pharmaceuticals Pvt. Ltd.
Naloxo-X
0.40mg
Rs 1,875.45 ceiling
Bajwa Pharmaceuticals (Pvt.) Ltd.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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