Drug Identity
Active Ingredient
Benzathine Penicillin
Drug Class
Beta-Lactamase Sensitive Penicillins
What is Benzyl Penicillin?
Uses
Benzathine Penicillin has the same antimicrobial activity as benzylpenicillin to which Benzathine Penicillin is hydrolyzed gradually foll...
How It Works
Administer by IV intermittent infusion over 15-60 min at a final concentration for administration of 100,000500,000 units/ml. A final concentration of 50,000 units/ml infused over 15-30 min is recommended for neonates and infants.
How to Take It
1
Adult · IM
0.6 to 1.2 million units — As recommended.
single dose every 3 weeks dose and duration may vary according to indication
2
Child · Intra Muscular
22.9 to 45.8 mg/kg — As recommended.
Every 5-7 Days
3
Child · Oral
22.9 mg/kg — 8 hourly
-
Safety Alerts
History of previous hypersensitivity reaction to penicillins and/or cephalosporins
Important Warnings
Avoid small ineffective doses of penicillin as resistant organisms are more likely to emerge, therapy must be sufficient to eliminate the streptococcal organism (a minimum of ten days), otherwise the sequela of streptococcal disease (endocarditis, rheumatic fever) may occur
Serious fatal immediate hypersensitivity (anaphylactoid) reactions have been reported
Do not inject parenteral solutions into or near an artery or nerve
Side Effects
GI disturbancesanaemiasanaphylaxisglossitisstomatitisgastritissore throatdry mouthfurry tongueHemorrhagic manifestationInterstitial nephritis (e.g oliguriahematuria)nephrotoxicity. Accumulation of sodium from injection can occur in renal failure. High doses may causeneurotoxicityincluding cerebral irritationconvulsions
Drug Interactions
Concurrent administration of bacteriostatic anti-biotics (e.g. erythromycin
tetracycline) may diminish the bactericidal effects of penicillins. Probenecid prolongs penicillin blood levels. Oral contraceptives may be rendered less effective & an increased incidence of breakthrough bleeding may occur when administered with ampicillin or penicillin V
Pregnancy & Lactation
Pregnancy
No evidence of harm
Lactation
Caution advised
Storage
Injections Store in a well closed container, Below 30°C.
Price Intelligence
Rs 1.98
DRAP approved maximum price · per unit · approved 01 Jul, 2024
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper unitRs 1.98
Should you consider an alternative?
Other options containing Benzathine Penicillin, and what they are not.
These contain this ingredient plus others. They are different medicines — do not swap.
Lapen
+ Penicillin
Rs 113.67
No DRAP alertsP.D.H. PHARMACEUTICALS (PVT) LTD.
Benzala
+ Benzathine Penicillin G
Rs 119.29
Macter International Limited
Benza
200mg
+ Albendazole, Penicillin
Rs 36.25 ceiling
The Searle Company Limited
Biotic-P
+ Benzathine Penicillin G, Penicillin, Penicillin G Benzathine
Rs 29.67 ceiling
English Pharmaceutical Indsutries
Benzibiotic
+ Benzathine Penicillin G, Penicillin, Penicillin-G Benzathine
Rs 46.87
Below approved ceilingM/s. Zafa Pharmaceutical Laboratories (Pvt) Ltd
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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