Drug Identity
Active Ingredient
Glucose
Drug Class
Pain Management
Chemical Class
Amide type
Pharmacological Group
on the basis of mechanism of action
ATC Code
B05CX01, V04CA02, V06DC01
Status
Essential Medicine
What is Bupicain SP?
Uses
Exparel (bupivacaine) is an anesthetic (numbing medicine) that is used after surgery to provide: Local analgesia (pain relief in a small ...
How It Works
Chemical Class
Amide type
Pharmacological Group
on the basis of mechanism of action
It is of Synthetic origin and belongs to Amide type. It belongs to Na-Channel Local Anesthetic antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Bupivacaine (HCl) is 288.43. It is weakly acidic drug, 5.38% solution of the drug is isotonic and Its pKa is not relevant.
How to Take It
1
Adult · Intra Thecal
50 to 100 mg — As recommended.
As Required
2
Child · Intra Thecal
1.25 mg/kg — As recommended.
As Required
Safety Alerts
You should not be treated with Exparel if you are allergic to bupivacaine
Before receiving Exparel, tell your doctor if you have had: an allergic reaction to any type of numbing medicine liver disease kidney disease heart disease a heart rhythm disorder or seizures
May cause fetal harm
Tell your doctor if you are pregnant
It may not be safe to breastfeed a baby while you are using this medicine
Important Warnings
Do not use for obstetrical paracervical block anesthesia
The safety and effectiveness of Exparel have not been established for postsurgical regional analgesia via other nerve blocks besides the ones approved above
Your healthcare provider will monitor your cardiovascular status, neurological status, and vital signs during and after injection of Exparel
Call your doctor if you have joint pain or stiffness, or weakness in any part of your body that occurs after your surgery, even months later
Should be used cautiously in people with liver disease because Exparel is metabolized by the liver
Patients with severe hepatic disease are at a greater risk of developing toxic plasma concentrations
Cases of methemoglobinemia (a rare blood disorder that affects how red blood cells deliver oxygen throughout your body) have been reported in association with local anesthetic use
Seek immediate medical attention if they or someone in their care experience the following signs or symptoms: pale, gray, or blue-colored skin (cyanosis)
Side Effects
Bupivacaine (HCl) produces potentially life-threatening effects which include Respiratory depressionRespiratory arrest. which are responsible for the discontinuation of Bupivacaine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Bupivacaine (HCl) include Metallic tasteTinnitusAnxietyIrrational behaviorCircumoral numbnessVisible brusin .The symptomatic adverse reactions produced by Bupivacaine (HCl) are more or less tolerable and if they become severethey can be treated symptomaticallythese include AnxietyTinnitusMetallic tasteShiveringCircumoral numbnessSomnolencePruritus generalized
Drug Interactions
Other drugs may interact with Exparel
including prescription and over-the-counter medicines
vitamins
and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using including: Lidocaine or other non-bupivacaine local anesthetics: Do not mix. Exparel may be administered at least 20 minutes or more following local administration of lidocaine Bupivacaine HCl: Do not exceed a milligram dose of bupivacaine HCl solution to Exparel of 1:2 when admixing
as this may impact the pharmacokinetics and/or physicochemical properties of the drugs.
Storage
Inj Store at room temperature. Do not Freeze. Protect from Sunlight.
Price Intelligence
Rs 382.75
DRAP approved maximum price · per pack of 5 · approved 22 Aug, 2025
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
No retail prices recorded
Should you consider an alternative?
Other options containing Glucose, and what they are not.
These contain this ingredient plus others. They are different medicines — do not swap.
Bupicain
50mg
Rs 41.94
LCPW
Unisol
100ml
Rs 133.02
No DRAP alertsUnisa Pharmaceutical Industries Limited DML: 000740
Nervlok
5mg/ml
Rs 210.78
SURGE
Bucan
10ml
Rs 210.78
BOSCH PHARMACEUTICALS (PVT) LTD.
Hospicaine
5mg/ml
Rs 210.78
SEARLE
Hospicaine
7.5mg/ml
Rs 276.99
SEARLE
Bupicain
10ml
Rs 285.2
LCPW
Bucane
5mg/ml
Rs 350.17
OPHTH-PHARMA (PVT) LTD.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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