Drug Identity
Active Ingredient
Chlorpromazine
Chemical Class
Phenothiazine
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
N05AA01
Status
Essential Medicine
What is Chlorotil?
mania
used to treat mania
schizophrenia
used to treat schizophrenia
How It Works
Chemical Class
Phenothiazine
Pharmacological Group
on the basis of mechanism of action and also classified in Antiemetic/Antivertigo Agents and Antipsychotic Agent pharmacological group
Chlorpromazine (HCl) also known as Thorazine, are the derivatives of Chlorpromazine (HCl). It is of Synthetic origin and belongs to Phenothiazine. It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Antiemetic/Antivertigo Agents and Antipsychotic Agent pharmacological group.The Molecular Weight of Chlorpromazine (HCl) is 318.86. Its pKa is 9.3.
How to Take It
1
Adult · IV,IM
25 to 50 mg — As recommended.
Repeated every 6-8 hours.
2
Adult · PO
25 mg — 8 hourly
3
Child · Intra Muscular
0.5 mg/kg — 6 hourly
Should not be used under 6 months of age.
4
Child · Intra Venous
0.5 mg/kg — 6 hourly
Should not be used under 6 months of age.
5
Child · Oral
0.5 mg/kg — 6 hourly
Should not be used under 6 months of age.
Safety Alerts
Chlorpromazine (HCl) is contraindicated in conditions like Epilepsy,Myasthenia gravis,Narrow-angle glaucoma,Parkinson's disease,Depressed level of conciousness
Important Warnings
Chlorpromazine should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal impairment, prostatic hypertrophy
Photosensitization may occur, caution patients to take appropriate measures (e
wear protective clothing or sunscreen) against exposure to sunlight or ultra violet light
Discontinue use at least 48 hours before myelography
Side Effects
WARNING/CAUTION: Even though it may be raresome people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reactionlike rashhivesitchingredswollenblisteredor peeling skin with or without feverwheezingtightness in the chest or throattrouble breathingswallowingor talkingunusual hoarseness
Drug Interactions
Chlorpromazine (HCl) is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholBelladonaAntimuscarinics reduce plasma concentration of phenothiazine (e.g Chlorpromazine)
but risk of antimuscarinic side-effects increased. Benzhexol (HCl)Benztropine (Mesylate)Antimuscarinics (e.g Benztropine) possibly reduce plasma concentration of Chlorpromazine.Bethanidine (Sulphate)Bovine InsulinCimetidine (HCl)Cimetidine reduces the therapeutic effects of chlorpromazine.MinorReduce the dose of chlorpromazine if necessaryClonidine (HCl)Clonidine (HCl)CyclophosphamideDebrisoquine (Sulphate)Dexamphetamine (Sulphate)DiazoxideEnhanced hypotensive effect when Diazoxide Chlorpromazine.DisulfiramEpirubicinFosphenytoinGlibornurideGliquidoneGuanethidineGuanethidineHalothaneHuman InsulinHydroxocobalaminImipramine (HCl)Insulin LisproLithiumMetacycline (HCl)Chlorpromazine (HCl)
fluphenazine and other phenothizines causes extrapyramidal reactions.Metformin (HCl)Chlorpromazine decreases the hypoglycemic effect of metformin by interfering with blood glucose control. ModerateClosely monitor the blood glucose level. Adjust the dose of metformin accordingly.MethyldopaMethyldopaMethylphenidate (HCl)Metoclopramide (HCl)Nalidixic AcidNitroglycerinsimultaneous use of nitroglycerin and phenothizines may cause orthostatic hypotension PerindoprilTheoretical potential for CHLORPROMAZINE increasing the HYPOTENSIVE effect of Perindopril Erbumine. ModeratePethidine (HCl)Phenytoin (Na)PiperazinePorcine InsulinPotassium ClorazepateEffects of Potassium Clorazepate may be potentiated by Chlorpromazine (HCl).PramipexoleChlorpromazine (HCl) may decrease the efficiency of pramipexole due to dopamine antagonism.Propranolol (HCl)ProtirelinRiboflavin (Vitamin B2)Chlorpromazine may lower riboflavin levels.TerazosinThalidomideVortioxetineincreases the level of vortioxetinemonitor closely
use alternative These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Syrup, Inj Store Below 40°C. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, Below 40°C. Protect from Sunlight.
Price Intelligence
Rs 406.64
DRAP approved maximum price · per pack of 1000 · approved 27 Jul, 2026
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 1000Rs 406.64
Should you consider an alternative?
Other options containing Chlorpromazine, and what they are not.
These contain this ingredient plus others. They are different medicines — do not swap.
PROCALM
100mg
Rs 323.95 ceiling
No DRAP alertsMS SIZA INTERNATIONAL PVT LTD.
Mosquit
500mg
+ Pyrimethamine, Sulfadoxine
Rs 1,067.76
No DRAP alertsPharmatec Pakistan (Pvt.) Limited
Mosquit
25mg
+ Pyrimethamine, Sulfadoxine
Rs 1,067.76 ceiling
No DRAP alertsFerozsons Laboratories Limited
Sartan
50Mg
+ Irbesartan, Losartan, Losartan Potassium
Rs 380Rs 38/unit
Below approved ceilingNo DRAP alertsBARRETT HODGSON PAKISTAN
Sartan
25mg
+ Irbesartan, Losartan, Losartan Potassium
Rs 75.28 ceiling
No DRAP alertsBARRETT HODGSON PAKISTAN (PVT) LTD.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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