Drug Identity
Active Ingredient
Clozapine
Drug Class
Psycholeptics; Antipsychotics, Anxiolytics, Hypnotics And Sedatives
Chemical Class
Diazepine
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
N05AH02
Status
Essential Medicine
What is Clozaril?
schizophrenia
used to treat schizophrenia in adults after other treatments have failed
How It Works
Chemical Class
Diazepine
Pharmacological Group
on the basis of mechanism of action and also classified in Psychotherapeutic Drugs pharmacological group
It is of Synthetic origin and belongs to Diazepine. It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs pharmacological group. The Molecular Weight of Clozapine is 326.82.
How to Take It
1
Adult · PO
12.5 mg — As recommended.
Once or twice on day 1.
2
Adult · PO
25 mg — As recommended.
Once or twice on day 2.
3
Adult · PO
25 to 50 mg — 12 hourly
Over 2-3 weeks.
4
Adult
Scraped Dose
Take clozapine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your
5
Child
Not recommended in this age group
Safety Alerts
Severe cardiac disorders(e
myocarditis), severe CNS depression, uncontrolledepilepsy, alcoholic and toxic psychoses, bone-marrow disorders,coma, drug intoxication, history of agranulocytosis, history of circulatory collapse, history of neutropenia,paralytic ileus
Important Warnings
Prostatic hypertrophy, susceptibility to angle-closure glaucoma, taper off other antipsychotics before starting
extreme caution if previous respiratory or cardiac arrest with initial dosing
Monitor leukocyte counts prior to treatment, then weekly during weeks 1-18, fortnightly for weeks 19-52, then every 4 weeks thereafter
withdraw immediately if low WBC count or low neutrophil count
Patients should report symptoms of infection
Use adequate contraception
Monitor patients with history ofepilepsy and liver disease
Side Effects
Anorexiahypersalivationagranulocytosisconstipationmalaisespeech disordersurinary incontinencehepatic disordershepatic failuremuscle disordersrenal failure. Rare: Circulatory collapsedysphagiahepatitismyocarditispancreatitis
Drug Interactions
: Other drugs which depress bone marrow function
CNS depressants
alcohol
MAOIs
benzodiazepines
lithium
antihistamines
anticholinergics
Pregnancy & Lactation
Pregnancy
Caution advised
Lactation
Contraindicated
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Price Intelligence
Rs 334.3
DVAGO observed price · per pack of 10 · as of 30 July 2026
Rs 33.43 per unit
Prices across sources
DRAPper pack of 50Rs 2,322.57
DVAGOper pack of 10Rs 334.3
Should you consider an alternative?
Other options containing Clozapine, and what they are not.
These contain this ingredient plus others. They are different medicines — do not swap.
Glipin
25Mg
Rs 184.3Rs 18.43/unit
Below approved ceilingGLITZ PHARMA
Amlepo
100mg
Rs 520Rs 52/unit
Below approved ceilingAMARANT HEALTHCARE
Saveril
100Mg
Rs 596.4Rs 59.64/unit
Below approved ceilingNo DRAP alertsGenetics Pharmaceuticals Pvt Ltd
Cloztec
25mg
Rs 1,574.46
PANACEA PHARMACEUTICALS
Zacloz
25mg
Rs 1,642.16
No DRAP alertsM/s. Genix Pharma (Pvt) Ltd.
Zalozapine
100mg
Rs 2,694.71
Mass Pharma (Pvt) Ltd.
Zacloz
100mg
Rs 3,231.53
No DRAP alertsM/s. Genix Pharma (Pvt) Ltd.
Tonitol CR
25mg
Rs 1,808.73 ceiling
No DRAP alertsNAWAN LABORATORIES (PVT) LTD.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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