Drug Identity
Active Ingredient
Actinomycin D
Drug Class
Antineoplastics
What is Dactinofin?
Uses
Actinomycin D is a highly toxic antibiotic with antineoplastic properties. Actinomycin D is isolated from Streptomyces chrysomallus and o...
How It Works
Infuse over 10-15 min. Avoid extravasation. Extremely damaging to soft tissue and will cause a severe local reaction if extravasation occurs. Administer slow IV push over 10-15 min. An in line cellulose membrane filter should not be used during administration of Dactinomycin soln. Do not give IM or SC. Dilute with 1.1 ml of preservative-free SWFI to yield a final concentration of 500 mcg/ml; do not use preservative diluent as precipitation may occur.
How to Take It
1
Adult · IV-inf
0.5 to 1 mg/m2 — 24 hourly
For 1-5 Days
2
Child · Intravenous
0.015 mg/kg — 24 hourly
For 1 to 5 days
Safety Alerts
Patients with concurrent or recent chickenpox or herpes zoster, anaphylactic reaction
Important Warnings
Use with caution in patients with blood disorder, gout, dental disease, heart disease, who have received radiation therapy
Avoid use within 2 months of radiation treatment for right-sided Wilms tumor, may increase the risk of hepatotoxicity
Discontinue treatment with severe myelo-suppression, diarrhoea or stomatitis
Avoid use in infants below 6 months age
Side Effects
Radiosensitization effectsbone marrow suppressionneutropenic feveranaphylactic reactionfatiguealopecia (reversible)Stevens-Johnson syndromegrowth retardationhyperuricemiaabdominal painanorexiadiarrhoeaGI ulcerationnauseavomiting
Drug Interactions
BCG
clozapine
natalizumab
pimecrolimus
tacrolimus (topical)
live vaccines (avoid)
leflunomide
roflumilast
Pregnancy & Lactation
Pregnancy
Positive evidence of risk: Avoid
Lactation
Contraindicated. Discontinue breast feeding
Storage
Powder for Inj Store Below 25°C. Do not Freeze.
Price Intelligence
Rs 444.03
DRAP approved maximum price · per unit · approved 01 Jul, 2025
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper unitRs 444.03
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