Drug Identity
Active Ingredient
Loperamide
Chemical Class
diphenylbutyramide
ATC Code
A07DA03
Status
Essential Medicine
What is Direarid?
Uses
Loperamide (HCl) is antidiarrheal agent. Loperamide (HCl) is chemically related to haloperidol, acting directly on the intestinal wall o ...
How It Works
Chemical Class
diphenylbutyramide
It is of Synthetic origin and belongs to diphenylbutyramide. It belongs to Antidiarrheal pharmacological group. The Molecular Weight of Loperamide (HCl) is 513.50. Its pKa is 8.7.
How to Take It
1
Adult · PO
4 to 16 mg — 24 hourly
Followed by 2mg/dose after each stool upto max dose of 16mg/day.
2
Adult
Scraped Dose
drink plenty of clear fluids to help prevent dehydration caused by diarrhea not for use in children under 12 years of age adults and children 12 years and over: 2 softgels after the first loose sto
3
Child · Oral
0.05 mg/kg — 6 hourly
-
Safety Alerts
Loperamide (HCl) is contraindicated in conditions like Acute dysentery, Pseudomembranous colitis, Bloody diarrhea, High fever, Infectious diarrhea, Pseudomembranous colitis
Important Warnings
Allergy alert: Do not use if you have ever had a rash or other allergic reaction to loperamide HCl Heart alert: Taking more than directed can cause serious heart problems or death Do not use if you have bloody or black stool in children under 12 years of age Ask a doctor before use if you have fever mucus in the stool a history of liver disease a history of abnormal heart rhythm Ask a doctor or pharmacist before use if you are taking a prescription drug
Loperamide may interact with certain prescription drugs
When using this product tiredness, drowsiness, or dizziness may occur
Be careful when driving or operating machinery
Stop use and ask a doctor if symptoms get worse diarrhea lasts for more than 2 days you get abdominal swelling or bulging
These may be signs of a serious condition
If pregnant or breast-feeding, ask a health professional before use
Keep out of reach of children
Side Effects
The signs and symptoms that are produced after the acute overdosage of Loperamide (HCl) include ConstipationSomnolenceBradypneaMuscular hypertoniaNeurological symptomsIleus. The symptomatic adverse reactions produced by Loperamide (HCl) are more or less tolerable and if they become severethey can be treated symptomaticallythese include DizzinessDrowsinessFatigueNauseaVomitingSkin reactionsAbdominal crampsUrticaria
Drug Interactions
Loperamide (HCl) is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCholestyramineColestipol (HCl)Desmopressin (Acetate)Plasma concentration of oral Desmopressin increased by Loperamide.Loperamide increase fastrointestinal absorption of desmopressin. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Liq Protect from Sunlight and Heat. Tab Store Below 40°C. Protect from Sunlight and Heat.
Price Intelligence
Rs 62.46
DRAP approved maximum price · per pack of 20 · approved 22 Aug, 2025
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 20Rs 62.46
Should you consider an alternative?
Other options containing Loperamide, and what they are not.
Identical active ingredient at the same strength. Cheapest per unit first.
Imodium
2Mg
Rs 72Rs 6/unit
Lowest price per unitBelow approved ceilingNo DRAP alerts
Floramex
2mg
Rs 87
Below approved ceilingM/s. Zafa Pharmaceutical Laboratories (Pvt) Ltd
Roljev
2mg
Rs 350.85
No DRAP alertsAKSON PHARMACEUTICALS (PVT) LTD.
LOPAMIDE
2mg
Rs 402.76 ceiling
MEDICAIDS PAKISTAN (PVT) LTD.
Dioraleze
2mg
Rs 274.9 ceiling
No DRAP alertsDavis Pharmaceutical Laboratories
Glodium
2mg
Rs 349.98 ceiling
Global Pharmaceuticals Pvt Ltd
Lopium
2mg
Rs 227.26 ceiling
No DRAP alertsArsons Pharmaceutical Industries (Pvt) Ltd
Neuoperide
2mg
Rs 285.13 ceiling
NEUTRO PHARMA (PVT) LTD.
Tymide
2mg
Rs 350.85 ceiling
No DRAP alertsArreta Pharmaceuticals (Pvt.) Ltd.
Dilop
2mg
Rs 40.46 ceiling
KAIZEN PHARMACEUTICALS PVT LTD.
Lopra
2mg
Rs 294.14 ceiling
IRZA PHARMA (PVT) LTD.
Medopril
2mg
Rs 334.34 ceiling
Caliph Pharmaceuticals (Pvt) Ltd.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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