250mg

Direto

DIRETO

Imipenem

S.J & G. Fazul Ellahie (pvt) limited.

Drug Identity

Active Ingredient

Imipenem

Drug Class

Other Beta-Lactam, Cephalosporins & Penems

What is Direto?

Uses

Imipenem is a ß lactam antibiotic derived from thienamycin. It has a wide spectrum with good activity against many gram negative, gram po...

How It Works

Administer by IV intermittent infusion; final concentration should not exceed 5 mg/ml; in fluid-restricted patients, a final concentration of 7 mg/ml has been administered; dose < 500 mg may be infused over 15-30 min; dose > 500 mg should be infused over 40-60 min. Administer by deep IM injection into a large muscle mass (such as the gluteal muscles or lateral part of the thigh) with a 21-gauge 2-inch needle. Aspiration is necessary to avoid inadvertent injection into a blood vessel.

How to Take It

Adult · IM

500 to 750 mg — 12 hourly

In combination with Cilastatin.

Adult · IV-inf

1 to 2 g — As recommended.

Daily in 3-4 div.doses, in combination with Cilastatin.

Child · IV Infusion

15 to 25 mg/kg — 6 hourly

Total dose should not exceed 2g.

Safety Alerts

Imipenem is contraindicated in conditions like Hypersensitivity

Important Warnings

Penicillin hypersensitivity, GI disease (particularly colitis), CNS disorders, renal dysfunction, epilepsy

Side Effects

Diarrhoeaeosinophilianausearashvomitingconfusiondizzinessdrowsinesshallucinationshypotensionleucopeniamyoclonicactivityseizuresthrombocytopeniathrombocytosis. Rare: Acute renal failure

Drug Interactions

Probenecid

ganciclovir.

Pregnancy & Lactation

Pregnancy

Avoid unless potential benefit outweighs risk.

Lactation

Caution advised, avoid

Storage

Inj Store Below 40°C.

Price Intelligence

Rs 873.06

DRAP approved maximum price · per unit · approved 05 Sep, 2025

No retail price observed for this pack. Retailers may not exceed the approved maximum.

Prices across sources

DRAPper unitRs 873.06

Should you consider an alternative?

Other options containing Imipenem, and what they are not.

Same active ingredient, a different dose. Never switch strength without your doctor or pharmacist.

Stanem

500mg

Rs 826.79Rs 826.79/unit

No DRAP alertsLCI Limited

Onemiv

500mg

Rs 958.58

Below approved ceilingNo DRAP alertsAspin Pharma

Onemiv

Rs 958.58

No DRAP alertsAspin Pharma

Cilenem

500mg

Rs 1,075.17

No DRAP alertsGenix Pharma Private Limited

Prepenem

500mg

Rs 1,846.42 ceiling

No DRAP alertsHIGHNOON LABORATORIES LIMITED

Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.

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