Drug Identity
Active Ingredient
Domperidone
Chemical Class
Antiemetic/Antivertigo Agents pharmacological group
What is Domprog?
Uses
Domperidone is an antiemetic (anti-sickness) and prokinetic drug. It belongs to a group of drugs called dopamine antagonists. It is used ...
How It Works
Chemical Class
Antiemetic/Antivertigo Agents pharmacological group
It is of Synthetic origin and benzimidazole derivative. It is structurally related to butyrophenone neuroleptics like haloperidol. It belongs to Antiemetic/Antivertigo Agents pharmacological group. The Molecular Weight of Domperidone is 425.90. Its pKa is 7.9.
How to Take It
1
Adult · PO
10 to 20 mg — 6 hourly
15-30 minutes before meal. It can be used for maximum 12 weeks.
2
Adult · Suppository
30 to 60 mg — 6 hourly
3
Adult
Scraped Dose
Always take this medicine exactly as your doctor or pharmacist tells you to. You should check with them if you are not sure. Your doctor will decide how long you will need to take this medicine. Ga
4
Child · Oral
250 to 0.4 ug/kg — 8 hourly
15-30 minutes before meal. It can be used for maximum 12 weeks. To a total daily dose of 80mg.
5
Child · Suppository
30 to 120 mg — 8 hourly
Safety Alerts
Do not take domperidone tablets if: You are allergic to domperidone or any of the other ingredients in it
Signs of an allergic reaction include: Rash Swallowing or breathing problems Swelling of your lips, face, throat or tongue You have a tumor of the pituitary gland (prolactinoma) You have a blockage or tear in your intestines You have black, tarry bowel motions (stools) or notice blood in your bowel motions
This could be a sign of bleeding in the stomach or intestines
You have a moderate or severe liver disease Your ECG (electrocardiogram) shows a heart problem called “prolonged QT corrected interval” You have or had a problem where your heart cannot pump the blood round your body as well as it should (condition called heart failure) You have a problem that gives you a low level of potassium or magnesium, or a high level of potassium in your blood You are taking certain medicines (see Interactions below) Do not take domperidone if any of the above applies to you
If you are not sure, talk to your doctor or pharmacist before taking this medicine
Important Warnings
Domperidone may cause an increased risk of heart rhythm disorder and cardiac arrest
This risk may be more likely in those over 60 years old or taking doses higher than 30 mg per day
The risk also increases when it is given together with some drugs
Tell your doctor or pharmacist if you are taking drugs to treat infection (fungal infections or bacterial infection) and/or if you have heart problems or AIDS/HIV
Domperidone should be used at the lowest effective dose in adults and adolescents 12 years of age and older and a body weight of 35kg or more
While taking this medicine, contact your doctor if you experience heart rhythm disorders such as palpitations, trouble breathing, loss of consciousness
Treatment with domperidone should be stopped
Side Effects
Domperidone can cause serious side effects. Stop taking domperidone and see your doctor or go to a hospital straightaway if: You get swelling of the handsfeetanklesfacelips or throat which may cause difficulty in swallowing or breathing. You may also notice an itchylumpy rash (hives) or nettle rash (urticaria). This may mean you are having an allergic reaction to this medicine. You notice any uncontrolled movements. These include irregular eye movementsunusual movements of the tongueand abnormal posture such as a twisted necktrembling and muscle stiffness. This is more likely to happen in children. These symptoms should stop once you stop taking this medicine. You have a very fast or unusual heartbeat. This could be a sign of a life-threatening heart problem. You have a fit (seizure). Common side effects of domperidone include: Dry mouth Uncommon side effects of domperidone include: Lowering of sexual drive (libido) in men Feeling anxious Feeling drowsy Headaches Diarrhea Itchy skin. You may also have a rash Unusual production of breast milk in men and women Painful or tender breasts A general feeling of weakness Other side effects (frequency unknown) of domperidone include: Disorders of the cardiovascular system: heart rhythm disorders (rapid or irregular heart beat) have been reportedif this happensyou should stop the treatment immediately. Domperidone may be associated with an increased risk of heart rhythm disorder and cardiac arrest. This risk may be more likely in those over 60 years old or taking doses higher than 30 mg per day. Feeling agitated or irritable Feeling more nervous than usual Abnormal eye movements Inability to urinate Breast enlargement in men In womenmenstrual periods may be irregular or stop A blood test shows changes in the way your liver is working Some patients who have used this medicine for conditions and dosages requiring longer term medical supervision have experienced the following unwanted effects: Restlessnessswollen or enlarged breastsunusual discharge from breastsirregular menstrual periods in women
Drug Interactions
Tell your healthcare provider about all the medicines you take
including prescription and over-the-counter medicines
vitamins
and herbal supplements. Do not take domperidone if you are taking medicine to treat: Fungal infections such as azole anti-fungals
specifically oral ketoconazole
fluconazole or voriconazole. Bacterial infections
specifically erythromycin
clarithromycin
Storage
Tab Store Below 25°C.
Price Intelligence
Rs 397.41
DRAP approved maximum price · per pack of 50 · approved 01 Jul, 2024
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 50Rs 397.41
Should you consider an alternative?
Other options containing Domperidone, and what they are not.
Identical active ingredient at the same strength. Cheapest per unit first.
Emidone
10mg
Rs 53.6Rs 5.36/unit
Lowest price per unitPHARMIX LINK DISTRIBUTOR
Domflash
10mg
Rs 347Rs 6.94/unit
No DRAP alertsNEXT PHARMA
Pelton
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Rs 85.5Rs 8.55/unit
GLOBAL PHARMACEUTICALS
Stomacol
10Mg
Rs 85.8Rs 8.58/unit
HIGH-Q INTERNATIONAL.
Motilium
10Mg
Rs 189.6Rs 9.48/unit
No DRAP alertsASPIN PHARMA
Motilium
10mg
Rs 95Rs 9.5/unit
No DRAP alertsASPIN PHARMA
Domel
10Mg
Rs 475Rs 9.5/unit
No DRAP alertsBARRETT HODGSON PAKISTAN
Peridone
10Mg
Rs 299.4Rs 9.98/unit
SAMI PHARM (PVT) LTD.
Domflashoro
10mg
Rs 254
No DRAP alertsNext Pharmaceutical Products (Pvt.) Ltd
Dovomit
10mg
Rs 283
No DRAP alertsNOVAMED
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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