Drug Identity
Active Ingredient
Lignocaine
Chemical Class
Amide
Pharmacological Group
on the basis of mechanism of action and also cl...
What is Dongcain?
Uses
Lignocaine is a sodium channel blocking agent, used as a local anesthetic and antiarrhythmic agent. It stabilizes nerve cell membranes to...
How It Works
Chemical Class
Amide
Pharmacological Group
on the basis of mechanism of action and also classified in Analgesic pharmacological group
Lignocaine also known as Lidocaine. Lidocaine (HCl) are the derivatives of Lignocaine. It is of Synthetic origin and belongs to Amide. It belongs to Na-Channel Local Anesthetic antagonist pharmacological group on the basis of mechanism of action and also classified in Analgesic pharmacological group. The Molecular Weight of Lignocaine is 234.30. It is weakly acidic drug, 4.00% solution of the drug is isotonic and Its pKa is 7.86.
How to Take It
1
Adult · IV Inf
2 to 4 mg/min — As recommended.
As Required
2
Adult · SC
4.5 mg/ kg /dose — As recommended.
Dose vary with procedure. do not repeat within two hours.
3
Adult · Topical
1 to 2 % — 3 hourly
As Required
4
Child · IV Infusion
20 to 50 ug/kg.min — As recommended.
Maintenance, As Required
5
Child · Slow IV
0.5 to 1 mg/kg — As recommended.
Initially, As Required
6
Child · Topical
2 % — 3 hourly
As Required
Safety Alerts
Lignocaine is contraindicated in conditions like Heart block, Bradycardia, Congestive heart failure, Hypersensitivity
Important Warnings
Lignocaine should be used with caution in patients receiving anti-coagulant therapy, with genetic predisposition of malignant hyperthermia, hypovolemia, shock and all types of heart block, congestive heart failure, bradycardia, respiratory depression or impaired liver or renal function
The injection of lignocaine should not be administered in areas of inflammation or infection
It should be avoided if plasma cholinesterase concentration is low
Side Effects
The severe or irreversible adverse effects of Lignocainewhich give rise to further complications include AllergyHypotensionBronchospasmComaSeizuresHypertensionTissue necrosisAnginaSinus bradycardiaRespiratory depressionBlurred visionTremorsMalignant hyperthermiaNeonatal depression
Drug Interactions
Lignocaine is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcuronium (Cl)Amphotericin BAmprenavirAmprenavir possibly increases plasma concentration of Lignocaine
increased risk of ventricular arrhythmias. ADVICE: Avoid concomitant use.MajorAtracurium (Besylate)Cimetidine (HCl)Cimitidine increases lignocaine toxicity.Edrophonium (Cl)EnfluraneFosphenytoinHalothaneNadololOxprenolol (HCl)PentazocinePropafenone (HCl)Propranolol (HCl)Propranolol reduces clearance of lignocaine.Rocuronium (Br)Suxamethonium (Cl)Suxamethonium (Cl)Timolol (Maleate)Tocainide (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Inj, Soln, Gel Store Between 15°C-30°C. Do not Freeze. Protect from Sunlight.
Price Intelligence
Price not recorded
No observed retail price and no approved ceiling matched to this pack.
Prices across sources
DRAPper 3.5mlRs 4.1
Should you consider an alternative?
Other options containing Lignocaine, and what they are not.
Same active ingredient, a different dose. Never switch strength without your doctor or pharmacist.
Xyloaid Jelly
2% 15G
Rs 69.92Rs 69.92/unit
No DRAP alertsBARRETT HODGSON PAKISTAN
Xylocainesolntop
50ml
Rs 69.12
No DRAP alertsBarrett Hodgson Pakistan (Private) Ltd.
Xyloaid Jelly
Rs 73.6
Below approved ceilingNo DRAP alertsBARRETT HODGSON PAKISTAN (PVT) LTD.
Xyloaidjelly
15g
Rs 73.6
No DRAP alertsBarrett Hodgson Pakistan (Private) Ltd.
Xylocaine
10ml
Rs 1,100.5
No DRAP alertsBARRETT HODGSON
Baligno
20mg/ml
Rs 673.92 ceiling
Bajwa Pharmaceuticals (Pvt.) Ltd.
Baligno
20mg
Rs 673.92 ceiling
Bajwa Pharmaceuticals (Pvt.) Ltd.
Ignocar
20mg
Rs 66.62 ceiling
Health care pharmaceuticals
Lagind
Rs 3.78 ceiling
BIO LABS (PVT) LTD.
Ligocane
10mg
Rs 6.24 ceiling
Global Pharmaceuticals Pvt Ltd
Medica
Rs 628.98 ceiling
No DRAP alertsMEDISAVE PHARMACEUTICALS
Logel
Rs 41.56 ceiling
Elite Pharma (Pvt) Ltd
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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