Drug Identity
Active Ingredient
Silver Sulphadiazine
Drug Class
Antibiotics For Topical Use
Chemical Class
Sulphonamide
Pharmacological Group
on the basis of mechanism of action and also cl...
What is Flamoff !%?
Uses
Sulphadiazine is antibacterial agent, belongs to Sulphonamide. It has a broad spectrum of activity, effective against gram positive, gram...
How It Works
Chemical Class
Sulphonamide
Pharmacological Group
on the basis of mechanism of action and also classified in Antibacterial pharmacological group
Sulphadiazine also known as Sulfadiazine. It is of Synthetic origin and belongs to Sulphonamide. It belongs to Dihydropteroate synthetase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibacterial pharmacological group. The Molecular Weight of Sulphadiazine is 250.30. It is weakly alkaline drug, 4.24% solution of the drug is isotonic and Its pKa is 6.4.
How to Take It
1
Adult · PO
0.5 to 1 g — 6 hourly
In Conjuction with pyrimethamine 25mg/day and with suplemental folinic acid. Doses could be given 2-4g/day in 3-6 divided doses.
2
Child · Oral
25 mg/kg — 6 hourly
Maintenance after 2 day IV maintenance doses
3
Child · Oral
37.5 mg/kg — 6 hourly
4
Child · Slow IV
25 mg/kg — 6 hourly
Maintenance for 2 Days
5
Child · Slow IV
50 mg/kg — 6 hourly
Initial
Safety Alerts
Hypersensitivity, infants, pregnancy and lactation
Important Warnings
Impaired renal or hepatic function
Side Effects
Itchingburning sensationirritationallergic reactionsargyrialeucopeniarashes
Drug Interactions
Sulphadiazine is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAscorbic AcidChlorpropamideMethotrexatePhenytoin (Na)ProcaineDecreased effect of sulfonamides with the PABA metabolite of procaine.PyrimethamineTolbutamideTorasemideSulphadiazine
a strong CYP2C9 inhibitor
may increase the serum concentration of Torasemide
a CYP2C9 substrate
by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Sulphadiazine is initiated
discontinued or dose changed.TrimethoprimWarfarin (Na)Sulphadiazine may decrease the metabolism of Warfarin.ModerateConsider an alternative drug in order to avoid toxicity of Warfarin. Some combinations are specifically contraindicated by manufacturers. Suggested dosage adjustments are also offered by some manufacturers. Please review applicable package inserts. Monitor for increased effects of Warfarin if Sulphadiazine is initiated/dose increased
and decreased effects if Sulphadiazine is discontinued/dose decreased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Tab, Inj Protect from Sunlight.
Price Intelligence
Rs 152.06
DRAP approved maximum price · per 50gm · approved 22 Aug, 2025
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper 50gmRs 152.06
Should you consider an alternative?
Other options containing Silver Sulphadiazine, and what they are not.
Same active ingredient, a different dose. Never switch strength without your doctor or pharmacist.
Savion
10mg
Rs 128.48
No DRAP alertsNIMRALL LABORATORIES
Sulzin
1%
Rs 152.06
BIO PHARMA
Biosilver
50g
Rs 157.57
BIO LABS (PVT) LTD.
Sentobe
10mg
Rs 361.15 ceiling
HOOVER PHARMACEUTICALS (PVT) LTD
Apver
10mg
Rs 105.96 ceiling
No DRAP alertsHamaz Pharmaceuticals (Pvt) Ltd.
Dynazin
Rs 256.27 ceiling
No DRAP alertsCCL Pharmaceuticals (Pvt.) Ltd.
Silvanext
Rs 222.85 ceiling
No DRAP alertsNext Pharmaceutical Products (Pvt.) Ltd
Extinzine
10mg
Rs 165.22 ceiling
Searle IV Solutions (Pvt) Ltd.
Sulzin
Rs 152.06 ceiling
Biogen Pharma
Bumo
10mg
Rs 182.2 ceiling
Focus & Rulz Pharmaceuticals (Pvt) Ltd
Civaz
10mg
Rs 261.65 ceiling
CIBEX (PRIVATE) LIMITED
SSD
Rs 232.27 ceiling
Glitz Pharma
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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