Gefticip

Severe renal or hepatic impairment, monitor LFTs, monitor for pulmonary toxicity, interrupt treatment and evaluate patient who develop pulmonary symptoms, risk factor for GI perforation

Ensure adequate contraception

withhold treatment if severe, low gastric pH (reduced absorption), electrolyte disturbances

During treatment if patients present with acute or worsening signs and symptoms suggestive of keratitis should be referred promptly to an opthalmology specialist

Treatment should be interupted or discontinued if ulcerative keratitis is diagnosed