Drug Identity
Active Ingredient
Mercaptopurine
Drug Class
Antineoplastics
Chemical Class
Hypoxanthine
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
L01BB02
Status
Essential Medicine
What is Mercaprine?
Uses
Mercaptopurine is used to treat acute lymphoblastic or lymphocytic leukemia. Mercaptopurine is sometimes given with other cancer medicati...
How It Works
Chemical Class
Hypoxanthine
Pharmacological Group
on the basis of mechanism of action and also classified in Antineoplastic Agent, Antimetabolite pharmacological group
Mercaptopurine (Monohydrate) also known as 6MP. It is of Synthetic origin and belongs to Hypoxanthine. It belongs to Antimetabolites (DNA acting) pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Antimetabolite pharmacological group. The Molecular Weight of Mercaptopurine (Monohydrate) is 170.20. Its pKa is 7.77, 11.17.
How to Take It
1
Adult · PO
75 to 100 mg/sq.m — 24 hourly
Initial
2
Adult · PO
100 to 175 mg/sq.m — 24 hourly
maintenance
3
Adult
Scraped Dose
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Shake the
Safety Alerts
Severe liver disease, severe bone marrow suppression, absent thiopurine methyltransferase activity
consider pre-treatment screening
Important Warnings
Renal or hepatic impairment
Monitor liver function and bloods, reduced thiopurine methyltransferase activity
Side Effects
Alopeciaanorexiabone-marrow suppressionhepatotoxicityhyperuricaemiamyelosuppressionliver toxicitynauseaoral mucositisthromboembolismtumourlysis syndromevomiting Rare: Pancreatitistransient oligospermiaIntestinal ulcerationlymphoma
Drug Interactions
Allopurinol
warfarin
olsalazine
mesalazine
sulphasalazine.
Pregnancy & Lactation
Pregnancy
Contraindicated in pregnancy.
Lactation
Contraindicated. Discontinue breast-feeding
Storage
Tab Store in a well closed container, Below 40°C.
Price Intelligence
Rs 457.35
DRAP approved maximum price · per pack of 30 · approved 01 Jul, 2025
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 30Rs 457.35
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