Drug Identity
Active Ingredient
Amiodarone
Drug Class
Cardiac Therapy
ATC Code
C01BD01
Status
Essential Medicine
What is Miodarone?
Uses
Amiodarone (HCl) is a potassium channel blocking agent. Amiodarone (HCl) is iodinated benzofuran derivative. It has been widely used as a...
How It Works
IV infusion over a period of 20 min to 2 hour. Diluted in 250 ml in 5% DW; may be followed by repeated infusions up to 1200 mg i.e. (approximately 15 mg/kg body wt) in up to 500 ml 5% DW per 24 hour, the rate of infusion based on clinical judgment. May be given by slow IV inj of 150-300 mg in 10-20 ml of 5% DW over 1-2 min.
How to Take It
1
Adult · IV Inf
5 mg/kg — As recommended.
Initially over 20-120 min with ECG monitoring. Max. 1.2 g in 24 hrs.
2
Adult · PO
200 mg — 24 hourly
Maintenance
3
Adult · PO
200 to 400 mg — 8 hourly
Load for 1-4 Weeks
4
Child · Oral
2.5 to 5 mg/kg — 24 hourly
Maintenance for 5-7 Days/week
5
Child · Oral
10 to 15 mg/kg — 24 hourly
Load for 4-14 Days
Safety Alerts
Avoid in severe conduction disturbances and in sinus node disease (unless pacemaker fitted), iodine sensitivity, sino-atrial heartblock and sinus bradycardia (except in cardiac arrest), thyroid dysfunction
With intravenous use avoid bolus injection in cardiomyopathy, avoid bolus injection in congestive heart failure, circulatory collapse, severe arterial hypotension, severe respiratory failure, all kinds of conduction delays, pulmonary fibrosis, severe liver parenthetic damage, women of child bearing age
Important Warnings
Acute porphyrias, conduction disturbances (in excessive dosage), elderly, heart failure, hypokalaemia, severe bradycardia, with intravenous use moderate and transient fall in blood pressure
risk of circulatory collapse precipitated by rapid administration or overdosage), severe hepatocellulartoxicity
Avoid prolonged sun or UV exposure during therapy & several months after discontinuation
Pregnancy should be avoided for the first year after therapy
Side Effects
Pulmonary toxicitydisturbances of liver & thyroid functionbradycardiahyperthyroidismhypothyroidismjaundicenauseaphototoxicityraised serum transaminasesreversible corneal Microdepositstaste disturbancestremorvomitinghot flusheshypotension
Drug Interactions
MAO inhibitors.
Pregnancy & Lactation
Pregnancy
Positive evidence of risk, use only when no safer alternative exists for a serious problem.
Lactation
Contraindicated, risk of neonatal hypothyroidism from release of iodine.
Storage
Inj Store at room temperature, Between 15°C-25°C. Protect from Sunlight. Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Price Intelligence
Rs 380.16
DRAP approved maximum price · per pack of 30 · approved 11 Aug, 2025
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
No retail prices recorded
Should you consider an alternative?
Other options containing Amiodarone, and what they are not.
Identical active ingredient at the same strength. Cheapest per unit first.
Cordarone
200mg
Rs 321.3Rs 32.13/unit
Lowest price per unitBelow approved ceilingSANOFI-AVENTIS PAKISTAN LTD.
E-Dran
200mg
Rs 388.3 ceiling
No DRAP alertsMEDERA PHARMACEUTICALS (PVT) LTD.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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