Drug Identity
Active Ingredient
Ondansetron
Chemical Class
Imidazole
ATC Code
A04AA01
Status
Essential Medicine
What is Onderon?
Uses
Ondansetron (HCl) is oral and parenteral antiemetic agent. Ondansetron (HCl) is the first selective serotonin blocking agent to be market...
How It Works
Chemical Class
Imidazole
It is of Synthetic origin and belongs to Imidazole. It belongs to Antiemetic/Antivertigo Agents and Selective 5-HT3 Receptor Antagonist pharmacological group. The Molecular Weight of Ondansetron (HCl) is 329.80. Its pKa is 7.4.
How to Take It
1
Adult · IV
0.15 to 0.45 mg/ kg — 4 hourly
Max. Dose =32 mg. Give 30 Min. before emetogenic drugs.
2
Adult · PO
8 mg — 8 hourly
Oral treatment is recommended for protection against delayed or prolonged emesis after first 24 hrs. Give upto 5 days.
3
Child · IV Infusion
5 mg/m2 — As recommended.
Initially for 15 Min (Rec. for 5-12 Yrs)
4
Child · Oral
4 mg — 2 hourly
Maintenance for 5 Days
Safety Alerts
Ondansetron (HCl) is contraindicated in conditions like Hypersensitivity
Important Warnings
Dosage restriction is advisable in patients with moderate to severe liver impairment
Ondansetron should be used with caution during pregnancy or lactation
Care is required in the patient exhibiting hypersensitivity to other selective 5HT3 receptor antagonists and in patient with signs of subacute intestinal obstruction
Side Effects
The severe or irreversible adverse effects of Ondansetron (HCl)which give rise to further complications include Cardiac arrhythmiasBronchospasmBradycardiaAngioedemaAnginaHyperbilirubinemia. The symptomatic adverse reactions produced by Ondansetron (HCl) are more or less tolerable and if they become severethey can be treated symptomaticallythese include DizzinessHeadacheFeverDyspneaConstipationAbdominal painChills
Drug Interactions
Ondansetron (HCl) is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepineBy concurrent use the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However
on the basis of available data
no dosage adjustment for ondansetron is recommended for patients on these drugs.No dosage adjustment for ondansetron is recommended for patients on these drugs.IndacaterolBoth indacaterol and ondansetron prolong the QT intervalconsider alternate therapyPhenytoin (Na)By concurrent use the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However
on the basis of available data
no dosage adjustment for ondansetron is recommended for patients on these drugs.No dosage adjustment for ondansetron is recommended for patients on these drugs.RifampicinBy concurrent use the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However
on the basis of available data
no dosage adjustment for ondansetron is recommended for patients on these drugs.No dosage adjustment for ondansetron is recommended for patients on these drugs.Tramadol (HCl)post operative analgesic activity of tramadol is decreased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Inj (reconstituted soln) Store at room temperature. Use within 24-48 hrs if kept at room temperature. Tab, Syrup, Suppositories Store at room temperature. Protect from Sunlight.
Price Intelligence
Rs 237.55
DRAP approved maximum price · per pack of 12 · approved 01 Jul, 2025
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 12Rs 237.55
Should you consider an alternative?
Other options containing Ondansetron, and what they are not.
Identical active ingredient at the same strength. Cheapest per unit first.
Xortron
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Rs 755.78
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Rs 925.05
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Neusiloc
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Rs 1,032.55
No DRAP alertsSolaris Life Sciences Private Limited,
Sharonoral
4mg
Rs 1,046.81
The Schazoo Pharmaceutical Laboratories (Pvt.) Ltd.
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Rs 997.25 ceiling
No DRAP alertsGENOME PHARMACEUTICALS (PVT) LTD
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Rs 1,046.82 ceiling
No DRAP alertsHIRANIS PHARMACEUTICALS PVT LTD
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Rs 954.65 ceiling
No DRAP alertsDANAS PHARMACEUTICALS (PVT) LTD
Ondace
4mg
Rs 798.82 ceiling
MEDISURE LABORATORIES PAKISTAN (PVT.) LTD.
Tcon
4mg
Rs 2,440.55 ceiling
No DRAP alertsTrigon Pharmaceuticals (Private) Ltd
Onseget
4mg
Rs 2,885.8 ceiling
Getz Pharma (Pvt.) Ltd.
Nixvom
4mg
Rs 1,001.79 ceiling
NABIQASIM INDUSTRIES (PVT) LTD.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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