Drug Identity
Active Ingredient
Methotrexate
Drug Class
Cancer
ATC Code
L01BA01, L04AX03
Status
Essential Medicine
What is Pharmatrexate?
Uses
Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone...
How It Works
It may be administered IM, IV or IT. IV administration may be slow push, short bolus infusion or 24-42 hour continuous infusion. Dilute powder with D5W or NS to a concentration of 25 mg/ml (20 mg and 50 mg vials) and 50 mg/ml (1 gm vial). Intrathecal solutions may be reconstituted to 2.5 to 5 mg/ml with NS, D5W, LR or Elliotts B solution. Use preservative free preparations for IT or high dose administration.
How to Take It
1
Adult · Intra Thecal
12 mg/sq.meter — As recommended.
Once a week
2
Adult · PO
2.5 mg — 24 hourly
In leukemia.
3
Adult · PO,IM
15 to 30 mg — 24 hourly
For 5 days in prophylaxis of choriocarcinoma.
4
Adult
Scraped Dose
YOU MAY NOT NEED TO TAKE METHOTREXATE EVERY DAY. This medicine is sometimes taken only once per week, or 2 to 4 times per week. Some conditions are treated daily for just a few days followed by a r
5
Child · Intra Muscular
5 to 15 mg/sq.meter — As recommended.
Per Week for Rheum. Arthritis
6
Child · Intra Venous
200 mg/sq.meter — As recommended.
For Induction
7
Child · IV Infusion
1200 mg/sq.meter — As recommended.
Maintenance, Over 24 Hours
8
Child · Oral
5 to 15 mg/sq.meter — As recommended.
Per Week for Rheum. Arthritis
Safety Alerts
Severe renal or hepatic impairment, Active infectious disease, immune deficiency syndrome, serious anaemia, leukopenia, thrombocytopenia, AIDS, pre-existing blood dyscrasias
Important Warnings
Hematological depression, chronic hepatic disease, psychiatric disorder, elderly, Perform blood, urine, hepatic and renal test
Risk of pneumonitis, patient should report the symptoms of dyspnoea, cough and fever
Acute porphyrias, photosensitivity
psoriasis lesions aggravated by UV radiation (skin ulceration reported), diarrhoea, extreme caution in blood disorders (avoid if severe), peptic ulceration, risk of accumulation in pleural effusion or ascites
drain before treatment, ulcerative colitis, ulcerative stomatitis
Side Effects
Alopeciaanaphylactic reactionsanorexiaarthralgiablood disorderschanges in nail & skin pigmentationchillschronic pulmonary fibrosisconfusionconjunctivitiscystitisdiarrhoeadrowsinessdyspepsiadysuria
Drug Interactions
Protein bound drugs
alcohol
live vaccine
folic acid
folate antagonist
anticonvulsants
NSAIDs
cyclosporin
Pregnancy & Lactation
Pregnancy
Contraindicated in pregnancy.
Lactation
Contraindicated. Discontinue breast-feeding
Storage
Tab, Inj Store in a well closed container, Below 40°C. Protect from Sunlight.
Price Intelligence
Rs 220
Servaid observed price · as of 30 July 2026
Prices across sources
DRAPper unitRs 407.02
ServaidRs 220
Should you consider an alternative?
Other options containing Methotrexate, and what they are not.
Same active ingredient, a different dose. Never switch strength without your doctor or pharmacist.
Unitrexate
2.5mg
Rs 1,062Rs 10.62/unit
No DRAP alertsKOREA UNITED PHARMA
Cytotrexate
2.5Mg
Rs 2,811Rs 28.11/unit
Below approved ceilingHOWARDS
CYTOTREXATE
10 MG
Rs 542.5Rs 54.25/unit
HOWARDS
Mextu
50mg
Rs 353.82
No DRAP alertsPUNJAB MEDICAL SERVICES DSL: 05-352-0063-041061D
Trexol
50mg
Rs 360.08
Helix Pharma (Pvt)., Ltd.
Mextu
500mg
Rs 2,286.25
No DRAP alertsPUNJAB MEDICAL SERVICES DSL: 05-352-0063-041061D
Mextu
1000mg
Rs 3,810.42
No DRAP alertsPUNJAB MEDICAL SERVICES DSL: 05-352-0063-041061D
Trexol
25mg
Rs 360.08 ceiling
Helix Pharma (Pvt)., Ltd.
Methorax
10mg
Rs 6,285.09 ceiling
No DRAP alertsGENOME PHARMACEUTICALS (PVT) LTD
Methorax
2.5mg
Rs 931.47 ceiling
No DRAP alertsGENOME PHARMACEUTICALS (PVT) LTD
Dmard
2.5mg
Rs 267.57 ceiling
Wilshire Laboratories (Private) Limited
Neumethoxate
2.5mg
Rs 3,104.91 ceiling
NEUTRO PHARMA (PVT) LTD.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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