Drug Identity
Active Ingredient
Metformin
Drug Class
Blood Glucose Lowering Drugs, Excluding Insulin
Chemical Class
Biguanide
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
A10BA02
Status
Essential Medicine
What is Piofitplus?
Uses
Metformin (HCl) is oral biguanide antidiabetic agent, introduced in 1950s. It reduces elevated blood glucose concentration in diabetic pa...
How It Works
Chemical Class
Biguanide
Pharmacological Group
on the basis of mechanism of action and also classified in Antidiabetic Agent, Biguanide pharmacological group
Metformin is the derivative of Metformin (HCl). It is of Synthetic origin and belongs to Biguanide. It belongs to Hypoglycemic pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Biguanide pharmacological group. The Molecular Weight of Metformin (HCl) is 165.62. Its pKa is 11.5.
How to Take It
1
Adult · PO
500 to 3000 mg — 12 hourly
Frequency may be increased upto 3times/day, if needed. Gradually increase upto 2-3 g/day.
2
Child
Not recommended in this age group
Safety Alerts
History of heart failure, previous or active bladder cancer, severe infection, shock, trauma, uninvestigated haematuria, dialysis, diabetic ketoacidosis, pregnancy and lactation
Important Warnings
Porphyrias, monitor for fluid retention or other signs of cardiac failure (discontinue if deteriorates)
Monitor for risk factors for lactic acidosis
Monitor for weight gain and anaemia
Withdraw 48 hours before elective surgery
Monitor for signs of hepatic dysfunction and check liver enzymes prior to therapy and every 2 months thereafter, elderly, risk of bone fracture and bladder cancer particularly in women and elderly
Side Effects
GI disturbancesanaemiaarthralgiadizzinesshaematuriaheadachehypoaesthesiaimpotenceoedemavertigovisual disturbancesweight gainaltered blood lipidsbladder cancerfatigue
Drug Interactions
Insulin (contraindicated)
NSAIDs
gemfibrozil
rifampicin. Insulin
gemfibrozil
rifampicin
NSAIDs
intravascular iodinated contrast media
Pregnancy & Lactation
Pregnancy
Contraindicated or not recommended
Lactation
Contraindicated or not recommended.
Storage
Tab Store in a well closed container, Between 15°C-30°C. Protect from Moisture.
Price Intelligence
Rs 192.4
Servaid observed price · as of 30 July 2026
No approved ceiling matched to this exact pack and strength.
Prices across sources
ServaidRs 192.4
Should you consider an alternative?
Other options containing Metformin, and what they are not.You pay Rs 72 more than the cheapest equivalent
Identical active ingredient at the same strength. Cheapest per unit first.
Zolid Plus
850mg
Rs 120.68Rs 17.24/unit
Lowest price per unitGETZ PHARMA PAKISTAN
Piozer Plus
850mg
Rs 279.3Rs 19.95/unit
HILTON PHARMA
Piomet
850mg
Rs 132.86
No DRAP alertsCCL Pharmaceuticals (Pvt.) Ltd. DML: 000052
Pozemet
850mg
Rs 132.86
No DRAP alertsAGP
Pio-M
850mg
Rs 392.42 ceiling
Amarant Pharmaceuticals Private Limited
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
For pharma professionalsCompany, market and opportunity intelligence
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