Drug Identity
Active Ingredient
Thiamine
Drug Class
Multivitamin, Combinations
Chemical Class
Thiopyrimidine
What is Polybion Z?
Uses
Fedratinib is used to treat intermediate-2 or high-risk primary or secondary myelofibrosis (MF) in adults, relieving night sweats, itchin...
How It Works
Chemical Class
Thiopyrimidine
Thiamine HCl (Vitamin B1) also known as Thiamin/Fursultiamine. It is of Synthetic origin and belongs to Thiopyrimidine. It belongs to Vitamin, Water Soluble pharmacological group. The Molecular Weight of Thiamine HCl (Vitamin B1) is 337.30. It is strongly acidic drug, 4.24% solution of the drug is isotonic and Its pKa is 4.8.
How to Take It
1
Adult · PO,IM
100 to 300 mg — 24 hourly
IV doses should be administered slowly atleast over 20 min to reduce Idiosyncratic reactions
2
Adult
Scraped Dose
Take fedratinib exactly as prescribed by your doctor. Follow all directions on your Inrebic (fedratinib) Package Insert and read all medication guides or instruction sheets. Your doctor may occasio
3
Child · Intra Muscular
1 mg/kg — 24 hourly
-
4
Child · Oral
1 mg/kg — 24 hourly
-
Safety Alerts
To make sure fedratinib is safe for you, tell your doctor if you: have low vitamin B1 (thiamine) levels have low red blood cell or platelet counts have or have had liver problems have or have had kidney problems have or have had eye problems are a current or past smoker have had a blood clot, heart attack, other heart problems, or stroke have or have had any other cancer are pregnant or plan to become pregnant are breastfeeding or plan to breastfeed
Fedratinib is not for use in patients under the age of 18 years
Important Warnings
Fedratinib carries a Boxed Warning for encephalopathy, including Wernicke's encephalopathy
Encephalopathy ( including Wernicke's encephalopathy)
A serious and sometimes fatal neurological problem called encephalopathy (including Wernicke's encephalopathy) has happened in some people who take fedratinib
Wernicke’s encephalopathy is a neurologic emergency that can happen if you do not have enough Vitamin B1 (thiamine) in your body
Your healthcare provider will do a blood test to check your Vitamin B1 level and treat you with Vitamin B1 if your level is too low before starting treatment with fedratinib
Your healthcare provider may also check your Vitamin B1 level during treatment and you should take a Vitamin B1 supplement (100 mg of thiamine) throughout treatment with fedratinib
Get emergency medical help right away if you develop the following: confusion, memory problems, or drowsiness problems with balance and movement, such as difficulty walking eye problems, such as double or blurred vision, or abnormal eye movements
Call your healthcare provider right away if you experience diarrhea, nausea, vomiting, and weight loss that does not get better with treatment
Side Effects
The most common side effects of fedratinib are: diarrhea nausea low red blood cell count (anemia) vomiting.
Drug Interactions
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take
which may increase side effects or make the medications less effective. Other drugs may interact with fedratinib
including prescription and over-the-counter medicines
vitamins
and herbal products . Tell your doctor about all your current medicines and any medicine you start or stop using. Especially tell your doctor if you are taking any of the following medicines: macrolide antibiotics (clarithromycin
erythromycin) antifungal medicines (itraconazole
ketoconazole
posaconazole
Storage
Inj Store Below 40°C. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, Below 40°C. Protect from Sunlight.
Price Intelligence
Rs 114
DVAGO observed price · per pack of 10 · as of 30 July 2026
Rs 11.4 per unit
No approved ceiling matched to this exact pack and strength.
Prices across sources
DVAGOper pack of 10Rs 114
Should you consider an alternative?
Other options containing Thiamine, and what they are not.
Same active ingredient, a different dose. Never switch strength without your doctor or pharmacist.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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