Drug Identity
Active Ingredient
Leflunomide
Drug Class
Pain Management
Chemical Class
Pyrimidine synthesis inhibitor
What is Rhulef?
Uses
Leflunomide affects the immune system and reduces swelling and inflammation in the body. Leflunomide is used to treat the symptoms of rhe...
How It Works
Chemical Class
Pyrimidine synthesis inhibitor
It is of Synthetic origin and belongs to Pyrimidine synthesis inhibitor. The Molecular Weight of Leflunomide is 270.20.
How to Take It
1
Adult · PO
100 mg — 24 hourly
For 3 days. Then 10-20 mg QD for maintenance.
2
Adult
Scraped Dose
Before you start treatment with leflunomide, your doctor may perform tests to make sure you do not have tuberculosis or other infections. Follow all directions on your prescription label. Your doct
Safety Alerts
Severe immunodeficiency, bone marrow dysfunction, blood dyscrasias, serious infections, hepatic impairment, moderate to severe renal insufficiency, severe hypoproteinaemia, ulcerative stomatitis
Contraception must be used by men and women during and for 2 years after use or until plasma levels fall below 0
Important Warnings
Anaemia, history of tuberculosis, impaired bone-marrow function, leucopenia, thrombocytopenia, risk of hepatotoxicity
monitor complete blood count & ALT before treatment and every 2 weeks for 6 months, then every 8 weeks
withdraw and washout if elevated and continue to monitor liver enzymes until normal
A washout procedure must be performed if toxicity or severe infection develops, or when switching to another disease-modifying antirheumatic drugs (DMARD) or for a desired preg-nancy
Side Effects
Abdominal painalopeciaanorexiaastheniadiarrhoeadizzinessdry skinheadacheincreased blood pressureleucopenianauseaoral mucosal disordersparaesthesiapruritusrash
Drug Interactions
Other DMARDs
alcohol
hepatotoxic
or haematotoxic drugs
methotrexate
drugs metabolised by CYP2C9 (not NSAIDs)
live vaccines
cholestyramine
Pregnancy & Lactation
Pregnancy
Contraindicated in pregnancy
Lactation
Contraindicated or not recommended
Price Intelligence
Rs 810
Servaid observed price · as of 30 July 2026
No approved ceiling matched to this exact pack and strength.
Prices across sources
ServaidRs 810
Should you consider an alternative?
Other options containing Leflunomide, and what they are not.You pay Rs 430 more than the cheapest equivalent
Identical active ingredient at the same strength. Cheapest per unit first.
Aidra
20mg
Rs 380Rs 38/unit
Lowest price per unitWILSHIRE LABORATORIES
RA-MIDE
20MG
Rs 1,425Rs 47.5/unit
HORIZON PHARMACEUTICALS
Cara
20Mg
Rs 579.5Rs 57.95/unit
S.J & G. FAZAL ELLAHIE
Lefora
20mg
Rs 626.1Rs 62.61/unit
HILTON PHARMA
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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