.jpg)
Drug Identity
Active Ingredient
Losartan
Drug Class
Cardiac Care
Chemical Class
Thiazide
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
C09CA01
Status
Essential Medicine
What is Sarcol-H?
Uses
Hydrochlorothiazide is a prototype drug of thiazide diuretics. Hydrochlorothiazide is antihypertensive agent. It increases the urination ...
How It Works
Chemical Class
Thiazide
Pharmacological Group
on the basis of mechanism of action and also classified in Antihypertensive Agent, Combination pharmacological group
It is of Synthetic origin and belongs to Thiazide. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agent, Combination pharmacological group. The Molecular Weight of Hydrochlorothiazide is 297.74. Its pKa is 7.9, 9.2.
How to Take It
1
Adult · PO
25 to 100 mg — 24 hourly
As Required
2
Child · Oral
2.5 mg/kg — 12 hourly
Safety Alerts
Hydrochlorothiazide is contraindicated in conditions like Diabetes mellitus, Gout, Renal diseases, Anuria, Hyperlipidemia, Liver diseases, ECG abnormalities
Important Warnings
May potentiate effects of other hypotensive agents
Although additive or potentiated antihypertensive effects usually are used to therapeutic advantage, hypotension could occur
(See Interactions
) Possible exacerbation or activation of systemic lupus erythematosus
Generally, do not use with lithium salts
(See Interactions
) May occur with or without history of allergy or bronchial asthma
Sulfonamide cross-sensitivity unlikely
Side Effects
The severe or irreversible adverse effects of Hydrochlorothiazidewhich give rise to further complications include PancreatitisStevens Johnson syndromeSystemic lupus erythematosusPneumonitisIdiosyncratic hypersensitivity reactions. Hydrochlorothiazide produces potentially life-threatening effects which include HyponatremiaMetabolic disturbancesIdiosyncratic hypersensitivity reactions. which are responsible for the discontinuation of Hydrochlorothiazide therapy. The signs and symptoms that are produced after the acute overdosage of Hydrochlorothiazide include ComaVolume depletionHypokalemiaHyperchloremic alkalosisHypersensitivity reactionsElectrolyte disturbancesLethargyHemolytic anemia
Drug Interactions
Hydrochlorothiazide is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlbuterolShould not use concurrently without doctors prescription.AlcoholAllopurinolconcomitant administeration can lead to impaired renal functionAmantadine (HCl)Amphotericin BIncreased risk of hypokalemia when amphotericin given with Hydrochlorothiazide.AstemizoleAzilisartan MedoxomilConcomitant administeration of Azilisartan and diuretics (e.g. hydrochlorothiazide) can lead to volume depletionCalciferolCarbamazepineIncreased risk of hyponatremia when Carbamazepine given with diuretics. Carbenoxolone (Na)Celiprolol (HCl)CholestyramineIt will reduce absorption of Hydrochlorothiazide from GIColestipol (HCl)DiazoxideEnhanced hypotensive effect when Diazoxide given with Hydrochlorothiaide.DiflunisalFluconazoleFosinopril (Na)Halofantrine (HCl)Indacaterolconcomitant therapy may increase risk of hypokalemiamonitor closelyInsulin Lispro ProtamineLithiumVolume depletion by Hydrochlorothiazide increases lithium absorption and causes Lithium toxicityMetformin (HCl)Thiazide (hydrochlorothiazide) antagonize the effect of metformin.MoxonidineConcomitant administration of moxonidine and hydrochlorothiazide is not indicated
as hypotensive effect of both drugs may be enhanced.Nebivolol (HCl)Concurrent use may decrease the extent of absorption of Nebivolol (HCl).PimozideConcomitant administeration can lead to prolong QT intervalPinacidil MonohydratePiroxicam-beta-cyclodextrinPiroxicam causes sodium
potassium and fluid retention and may interfere with natriuretic action of diuretic agents (e.g hydrochlorothiazide) and thus precipitate the heart failurePropranolol (HCl)Riboflavin (Vitamin B2)Hydrochlorothiazide
may cause you to excrete more riboflavin in your urine.Rutin (Vitamin P)Rutin may have additive effects when used in combination with Hydrochlorothiazide.Sodium PhosphateShould not be use concurrently without doctors prescription.Sotalol (HCl)TenoxicamNSAIDs may cause sodium
potassium and fluid retention and may interfere with the natriuretic action of diuretic agents
which can increase the risk of nephrotoxicity of NSAIDs.TerfenadineConcomitant administeration can lead to prolong QT intervalTetracycline (HCl)TrimethoprimTubocurarine (Cl) Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Store in a well closed container, at room temperature. Protect from Moisture and Heat. Tab Store Below 40°C. Protect from Sunlight and Heat.
Price Intelligence
Rs 399.8
DVAGO observed price · per pack of 20 · as of 30 July 2026
Rs 19.99 per unit
No approved ceiling matched to this exact pack and strength.
Prices across sources
ServaidRs 345
DVAGOper pack of 20Rs 399.8
Should you consider an alternative?
Other options containing Losartan, and what they are not.You pay Rs 225 more than the cheapest equivalent
Identical active ingredient at the same strength. Cheapest per unit first.
Qsartan Plus
12.5Mg
Rs 211.1Rs 21.11/unit
Lowest price per unitHIGH-Q INTERNATIONAL.
Zostat Plus
12.5mg
Rs 478.8Rs 47.88/unit
No DRAP alertsHIMONT PHARMA (PVT) LTD
Xavordiu
12.5mg
Rs 175
No DRAP alertsFEROZSONS
Giozard
12.5mg
Rs 330
No DRAP alertsP.D.H. PHARMACEUTICALS (PVT) LTD.
Nonsart
12.5mg
Rs 376
HORIZON
Lotenseh
12.5mg
Rs 387
No DRAP alertsSchazoo Laboratories (Pvt) Ltd
Coeziday
12.5mg
Rs 390
Werrick Pharmaceuticals Pakistan
Coa2A
12.5mg
Rs 396.2
WILSONS PHARMACEUTICALS
Losarplus
12.5mg
Rs 400
PLATINUM
Hyzaar
12.5mg
Rs 1,451.52
SEARLE
Jesper Plus
12.5mg
Rs 588.86 ceiling
No DRAP alertsUniMark Pharmaceuticals Pvt. Ltd.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
Often Bought Together
Onato-V — Onato-V Tablets 5Mg/80Mg (1 Box = 2 Strips) (1 Strip = 7 Tablets)Rs 323.12Masdipine Sr — Masdipine Sr Tablets 30Mg (1 Strip = 10 Tablets)Rs 248.9Tenormin — Tenormin Tablets 50Mg (1 Box = 1 Strip)(1 Strip = 21 Tablets)Rs 359.73Tenormin — Tenormin Tablets 25Mg (1 Box = 1 Strip)(1 Strip = 21 Tablets)Rs 204.33Tenormin — Tenormin Tablets 100Mg (1 Box = 1 Strip)(1 Strip = 21 Tablets)Rs 548.94
For pharma professionalsCompany, market and opportunity intelligence
Company
40
brands
35
molecules
0
alerts