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Aluminium Hydroxide and Oxide is known to interact with other drugs

the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlfacalcidolit increases or potentiate hypercalcemiaAzithromycinPeak serum drug concentration of azithromycin is decreased.Azithromycin should be given 1 hour before or after 2 hour of antacid.CalcitriolCarbenoxolone (Na)CefpodoximeCeftibutenTake antacid a part from the doses of ceftibutin.Chenodeoxycholic AcidChlordiazepoxide (HCl)ChloroquineCimetidine (HCl)Citric AcidClopidogrelAluminium Hydroxide and Oxide do not appear to affect serum concentration of Clopidogrel. N/ANo action required.DeferasiroxDeflazacortDiacereinDecreased absorption with aluminium and/or magnesium hydroxide antacids. Take with at least two hours difference.DiflunisalDiflunisalDigoxinAluminium hydroxide may decrease the serum concentration of digoxin.MinorNo action required.Ethambutol (HCl)Etidronate (Disodium)FluorideHydroxychloroquine (Sulphate)IndomethacinIron SaltsIsoniazidKetoconazoleLevofloxacinAluminium and magnesium hydroxide containing antacids

and products containing calcium

ion and zinc salts reduce the absorption of levofloxacin.MeclofenamateConcomitant administration of aluminum hydroxides does not interfere with absorption of meclofenamate sodium.NaproxenNorfloxacinOfloxacinOlanzapineOxethazaine The use of aluminum containing antacids is contraindicated in patients with symptoms of appendicitis since these products may increase the danger of perforation or rupture due to their constipating or laxative effects.Phenylbutazone Prednisolone and Prednisone Aluminium Hydroxide and Oxide impair absorption of prednisolone and prednisonePropranolol (HCl)Pseudoephedrine (HCl)aluminium hydroxide incerases the absorbtion of Pseudoephedrine (HCl)RanitidineRifampicinRisedronate (Na)Aluminium Hydroxide and Oxide will interfere with the absorption of Risedronate (Na).SimethiconeThis interaction is sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. Sodium ClodronateSodium Polystyrene SulphonateSTRONTIUM RANELATEA 20-25% decrease in the extent of oral strontium ranelate absorption is documented with aluminium/magnesium hydroxide

when given simultaneously or two hours before strontium. Absorption was negligibly affected with administration of the antacid two hours after strontium.MinorAdminister antacids two hours after strontium ranelate. Strontium ranelate is best taken at bedtime. Strontium-89 ChlorideSaturation of bone-binding sites by calcium may reduce uptake of strontium-89 chloride. ModerateSulfolaxSulfolax docusate may increase the toxicity of Aluminium Hydroxide and Oxide by increasing intestinal absorption of the drug. ModerateConcurrent use should be avoided.TadalafilSimultaneous administration of an antacid aluminium hydroxide and oxide and tadalafil reduced the apparent rate of absorption of tadalafil without altering exposure (AUC) to tadalafil.Technetium Tc-99m OxidronateHigh blood concentrations of aluminum ion

which may occur in patients with gastrointestinal obstruction or impaired renal function

may cause localization of technetium Tc 99m oxidronate in the liver.Tetracycline (HCl)Tetracycline (HCl)Thiamine HCl (Vitamin B1)Antacids may lower thiamin levels in the body by decreasing absorption and increasing excretion or metabolism.Zalcitabine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.