Drug Identity
Active Ingredient
Rituximab
Drug Class
Antineoplastics
ATC Code
L01XC02
Status
Essential Medicine
What is Tuximab?
Uses
Rituximab infusion is used to treat certain leukemias and lymphomas and some non-cancer conditions, such as rheumatoid arthritis, polyang...
How It Works
Do not administer as an IV push or bolus, dilute to final conc. of 1-4 mg /ml into an infusion bag containing either NS or D5W. Interrupt rituximab infusion for severe reactions and resume at a 50% reduction in rate (e.g. from 100 to 50 mg/hours) when symptom have completely resolved. In most cases, patients who have experienced nonlife-threatening reactions have been able to complete the full course of therapy.
How to Take It
1
Adult · IV-Inf
375 mg/m2 — As recommended.
Once weekly for 4 doses.
Safety Alerts
Severe heart failure, severe infection, severe, uncontrolled heart disease (when used to treat granulomatosis with polyangiitis or microscopic polyangiitis)
Important Warnings
History of pulmonary insufficiency, pulmonary tumour infiltration
History of cardiovascular disease
in adults exacerbation of angina, arrhythmia, and heart failure have been reported, patients receiving cardiotoxic chemotherapy, Withhold antihypertensive medications 12 hrs prior to and throughout infusion, fewer neutrophil and platelet count, infusion reaction, infection, immunization, Use effective contraception method during and for 12 months after treatment
Patients should be monitored for cognitive, neurological, or psychiatric signs and symptoms
If progressive multifocal leucoencephalopathy is suspected, suspend treatment until it has been excluded
Side Effects
Abdominal painanaemiaaplastic anaemiaarthralgiaastheniablood disordersdepressiondyspepsiahypertensionhypotensionleucopenialupus erythematosus-like syndromemigrainemuscle spasmpancytopenia
Drug Interactions
Tell your healthcare provider about all the medicines you or your child takes
including prescription and over-the-counter medicines
vitamins
and herbal supplements. Especially tell your healthcare provider if you or your child takes or has taken: a Tumor Necrosis Factor (TNF) inhibitor medicine such as adalimumab
certolizumab
etanercept
or golimumab
infliximab a Disease Modifying Anti-Rheumatic Drug (DMARD) such as leflunomide
Pregnancy & Lactation
Pregnancy
Positive evidence of risk: Avoid
Lactation
Contraindicated. Discontinue breast-feeding
Storage
Inj Store . Do not Freeze. Protect from Sunlight and Heat.
Price Intelligence
Rs 116,196.57
DRAP approved maximum price · per unit · approved 23 Jul, 2026
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper unitRs 116,196.57
Should you consider an alternative?
Other options containing Rituximab, and what they are not.
Identical active ingredient at the same strength. Cheapest per unit first.
Rituxim
500mg
Rs 89,815.63
PHARMEVO (PVT) LTD.
Ximab
500mg
Rs 89,815.63 ceiling
Helix Pharma (Pvt)., Ltd.
Ristova
500mg
Rs 176,590.37 ceiling
ROCHE PAKISTAN LTD.
Ruxience
500mg
Rs 79,017.08 ceiling
Pfizer Pakistan Limited
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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