Drug Identity
Active Ingredient
Metoclopramide
Chemical Class
Benzamide
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
A03FA01
Status
Essential Medicine
What is Unexolone?
Uses
Metoclopramide (HCl) is antiemetic with dopamine antagonist action in brain and peripheral effect on gastro-intestinal tract where it sti...
How It Works
Chemical Class
Benzamide
Pharmacological Group
on the basis of mechanism of action and also classified in Histamine (H-2) Antagonists and GI Agent, Prokinetic pharmacological group
Metoclopramide is the derivative of Metoclopramide (HCl). It is of Synthetic origin and belongs to Benzamide. It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Histamine (H-2) Antagonists and GI Agent, Prokinetic pharmacological group. The Molecular Weight of Metoclopramide (HCl) is 299.80. Its pKa is 4.45, 9.2.
How to Take It
1
Adult · PO,IV,IM
10 to 15 mg — 6 hourly
Renal dysfunction: decrease dose.
2
Child · Intra Muscular
0.1 to 0.2 mg/kg — 8 hourly
-
3
Child · Intra Venous
0.1 to 0.2 mg/kg — 8 hourly
-
4
Child · Oral
0.1 to 0.2 mg/kg — 8 hourly
-
Safety Alerts
Metoclopramide (HCl) is contraindicated in conditions like Parkinsonism, Pheochromocytoma, Pyloric stenosis, Dystonia
Important Warnings
Patient should observe caution while driving or performing other tasks requiring alertness because it may produce drowsiness
Metoclopramide should be used with caution in patients with previously detected breast cancer
Children, Young adults & elderly should be treated with care as they are at increased risk of extrapyramidal reactions
Care should be taken when metoclopramide is given to patients with renal or hepatic impairment
Side Effects
The severe or irreversible adverse effects of Metoclopramide (HCl)which give rise to further complications include Tardive dyskinesiaParkinsonismAcute dystoniaAcute porphyriaAcute dyskinesiaExtrapyramidal reactions. The signs and symptoms that are produced after the acute overdosage of Metoclopramide (HCl) include TachycardiaDrowsinessDystonia. The symptomatic adverse reactions produced by Metoclopramide (HCl) are more or less tolerable and if they become severethey can be treated symptomaticallythese include DrowsinessDiarrheaAkathisiaSkin rashImpotence
Drug Interactions
Metoclopramide (HCl) is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinAtovaquonePlasma concentration of Atovaquone reduced by Metoclopramide. Atropine (Sulphate)Barium SulphateBenorylateBiperiden (HCl)Bromocriptine (Mesylate)Hypoprolactenamic effect of bromocriptine possibly antagonized by Metoclopramide.CabergolineHypoprolactinemic effect of Cabergoline possibly antagonized by Metoclopramide.Chlordiazepoxide (HCl)ChlorothiazideChlorpromazine (HCl)ChlorprothixeneCholine Magnesium TrisalicylateCimetidine (HCl)ClozapineCyclosporin AMetoclopramide increases the bioavailability of cyclosporinby increasing gastric emptying and may interfere with gastrointestinal degradation of cyclosporin
thus increases the risk of toxicity.ModerateCarefully monitor cyclosporin level
renal function and serum creatinine level of patient.DigitoxinDigoxinDroperidolFlupenthixol (HCl and Decanoate)FluphenazineFosfomycinFosinopril (Na)Gonadorelin (HCl)HaloperidolLevodopaMetoclopramide antagonize the pharmacological effect of levodopa. Central nervous system depressent effect of both of these agents synergistically increased.ModeratePatient should be alerted to drowsiness.LevosulpirideLithiumMolindoneConcurrent use with Molindone increases certain serious side effects.OlanzapineOxycodoneParacetamolPergolidePiribedilMetoclopramide (HCl) reduce the effect of piribedil.PramipexoleMetoclopramide (HCl) may decrease the efficiency of pramipexole due to dopamine antagonism.PrazepamQuetiapineRisperidoneZopicloneZuclopenthixol These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Inj (reconstituted soln) Store at room temperature. Use within 24 hrs if kept at room temperature. Syrup, Inj Store Below 40°C. Do not Freeze. Protect from Sunlight. Tab, Oral Soln Store in a well closed container, Below 40°C. Protect from Sunlight.
Price Intelligence
Rs 982.44
DRAP approved maximum price · per pack of 500 · approved 27 Jul, 2026
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 500Rs 982.44
Should you consider an alternative?
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Identical active ingredient at the same strength. Cheapest per unit first.
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Rs 157.45 ceiling
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Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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