Drug Identity
Active Ingredient
Hydrochlorothiazide
Chemical Class
Thiazide
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
C03AA03
Status
Essential Medicine
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Uses
Hydrochlorothiazide is a prototype drug of thiazide diuretics. Hydrochlorothiazide is antihypertensive agent. It increases the urination ...
How It Works
Chemical Class
Thiazide
Pharmacological Group
on the basis of mechanism of action and also classified in Antihypertensive Agent, Combination pharmacological group
It is of Synthetic origin and belongs to Thiazide. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agent, Combination pharmacological group. The Molecular Weight of Hydrochlorothiazide is 297.74. Its pKa is 7.9, 9.2.
How to Take It
1
Adult · PO
25 to 100 mg — 24 hourly
As Required
2
Child · Oral
2.5 mg/kg — 12 hourly
Safety Alerts
Hydrochlorothiazide is contraindicated in conditions like Diabetes mellitus, Gout, Renal diseases, Anuria, Hyperlipidemia, Liver diseases, ECG abnormalities
Important Warnings
May potentiate effects of other hypotensive agents
Although additive or potentiated antihypertensive effects usually are used to therapeutic advantage, hypotension could occur
(See Interactions
) Possible exacerbation or activation of systemic lupus erythematosus
Generally, do not use with lithium salts
(See Interactions
) May occur with or without history of allergy or bronchial asthma
Sulfonamide cross-sensitivity unlikely
Side Effects
The severe or irreversible adverse effects of Hydrochlorothiazidewhich give rise to further complications include PancreatitisStevens Johnson syndromeSystemic lupus erythematosusPneumonitisIdiosyncratic hypersensitivity reactions. Hydrochlorothiazide produces potentially life-threatening effects which include HyponatremiaMetabolic disturbancesIdiosyncratic hypersensitivity reactions. which are responsible for the discontinuation of Hydrochlorothiazide therapy. The signs and symptoms that are produced after the acute overdosage of Hydrochlorothiazide include ComaVolume depletionHypokalemiaHyperchloremic alkalosisHypersensitivity reactionsElectrolyte disturbancesLethargyHemolytic anemia
Drug Interactions
Hydrochlorothiazide is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlbuterolShould not use concurrently without doctors prescription.AlcoholAllopurinolconcomitant administeration can lead to impaired renal functionAmantadine (HCl)Amphotericin BIncreased risk of hypokalemia when amphotericin given with Hydrochlorothiazide.AstemizoleAzilisartan MedoxomilConcomitant administeration of Azilisartan and diuretics (e.g. hydrochlorothiazide) can lead to volume depletionCalciferolCarbamazepineIncreased risk of hyponatremia when Carbamazepine given with diuretics. Carbenoxolone (Na)Celiprolol (HCl)CholestyramineIt will reduce absorption of Hydrochlorothiazide from GIColestipol (HCl)DiazoxideEnhanced hypotensive effect when Diazoxide given with Hydrochlorothiaide.DiflunisalFluconazoleFosinopril (Na)Halofantrine (HCl)Indacaterolconcomitant therapy may increase risk of hypokalemiamonitor closelyInsulin Lispro ProtamineLithiumVolume depletion by Hydrochlorothiazide increases lithium absorption and causes Lithium toxicityMetformin (HCl)Thiazide (hydrochlorothiazide) antagonize the effect of metformin.MoxonidineConcomitant administration of moxonidine and hydrochlorothiazide is not indicated
as hypotensive effect of both drugs may be enhanced.Nebivolol (HCl)Concurrent use may decrease the extent of absorption of Nebivolol (HCl).PimozideConcomitant administeration can lead to prolong QT intervalPinacidil MonohydratePiroxicam-beta-cyclodextrinPiroxicam causes sodium
potassium and fluid retention and may interfere with natriuretic action of diuretic agents (e.g hydrochlorothiazide) and thus precipitate the heart failurePropranolol (HCl)Riboflavin (Vitamin B2)Hydrochlorothiazide
may cause you to excrete more riboflavin in your urine.Rutin (Vitamin P)Rutin may have additive effects when used in combination with Hydrochlorothiazide.Sodium PhosphateShould not be use concurrently without doctors prescription.Sotalol (HCl)TenoxicamNSAIDs may cause sodium
potassium and fluid retention and may interfere with the natriuretic action of diuretic agents
which can increase the risk of nephrotoxicity of NSAIDs.TerfenadineConcomitant administeration can lead to prolong QT intervalTetracycline (HCl)TrimethoprimTubocurarine (Cl) Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Store in a well closed container, at room temperature. Protect from Moisture and Heat. Tab Store Below 40°C. Protect from Sunlight and Heat.
Price Intelligence
Rs 435.95
DRAP approved maximum price · per pack of 28 · approved 27 Jul, 2026
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 28Rs 435.95
Should you consider an alternative?
Other options containing Hydrochlorothiazide, and what they are not.
Identical active ingredient at the same strength. Cheapest per unit first.
Valtec AMH
12.5mg
Rs 370.44Rs 13.23/unit
Lowest price per unitTABROS PHARMA
Valtec AMH
12.5mg
Rs 397.04Rs 14.18/unit
TABROS PHARMA
Onato-V HCT
12.5mg
Rs 399Rs 14.25/unit
SAMI PHARM (PVT) LTD.
Triforge
12.5Mg
Rs 106.4Rs 15.2/unit
No DRAP alertsHIGHNOON LABORATORIES LTD.
Triforge
12.5Mg
Rs 490.28Rs 17.51/unit
No DRAP alertsHIGHNOON LABORATORIES LTD.
Sofvasc Hct
12.5Mg
Rs 253.96Rs 18.14/unit
WILSONS PHARMACEUTICALS
Sofvasc HCT
12.5mg
Rs 253.96Rs 18.14/unit
WILSONS PHARMACEUTICALS
Valam-H
12.5mg
Rs 133.21Rs 19.03/unit
No DRAP alertsC.C.L (PVT) LTD .
Amodip-V Plus
12.5mg
Rs 399Rs 28.5/unit
MASS PHARMA (PVT) LTD.
Co-Extor
12.5Mg
Rs 409.5Rs 29.25/unit
SEARLE PAKISTAN (PVT) LTD.
Co-Extor
12.5Mg
Rs 478.38Rs 34.17/unit
SEARLE PAKISTAN (PVT) LTD.
Avsarplus
12.5mg
Rs 311.08
Below approved ceilingPHARMEVO (PVT) LTD.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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