VENICE XR

Venlafaxine (HCl) is known to interact with other drugs

the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCimetidine (HCl)DiphenhydramineParegoricCentral nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects

especially in elderly or debilitated patients.ModerateDuring concomitant use of these drugs

patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g.

drowsiness

dizziness

lightheadedness

confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.VORICONAZOLEVoriconazole may increase the serum concentration of venlafaxine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects Vortioxetineincreases toxicity of vortioxetineuse alternative These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.