Drug Identity
Active Ingredient
Propyphenazone
Drug Class
Other Analgesics And Antipyretics
Chemical Class
Methyl Xanthine class
Pharmacological Group
on the basis of mechanism of action and also cl...
What is Vio-Zone?
Uses
Caffeine is a central nervous system stimulant. It works by stimulating the brain. Caffeine is found naturally in foods and beverages suc...
How It Works
Chemical Class
Methyl Xanthine class
Pharmacological Group
on the basis of mechanism of action and also classified in CNS Stimulant pharmacological group
Caffeine also known as Methyl Theobromine, Methyl Theobromine, Methyl Theobromine. It is of Natural origin and belongs to Methyl Xanthine class. It belongs to Phosphodiesterase inhibitor pharmacological group on the basis of mechanism of action and also classified in CNS Stimulant pharmacological group. The Molecular Weight of Caffeine is 194.20. Its pKa is 13.9.
How to Take It
1
Adult · PO,IV
100 to 200 mg — As recommended.
2
Child · Intravenous
2.5 — As recommended.
Maintenance
3
Child · Intravenous
10 mg/kg — As recommended.
Load for Once
4
Child · Oral
2.5 mg/kg — As recommended.
Maintenance, As Required
5
Child · Oral
10 mg/kg — As recommended.
Load for Once
Safety Alerts
Porphyrias, avoid regular use as analgesic
Important Warnings
Caffeine should be used with caution in diabetic patients because it may produced hyperglycemia, in anxiety disorder or panic disorder because it can aggravate these conditions, in hepatic disease or hepatic impairment and during pregnancy and breast feeding
Side Effects
difficulty sleeping (insomnia) nervousness or anxiety irritability nausea headache Seek medical attention right away if any of these severe side effects occur: serious allergic reactions (difficult breathingchest tightnessswelling of the mouthfacelipsor tonguerashhivesor itching) diarrhea vomiting rapid heart rate or palpitations increased blood pressure chest pain This is not a complete list of all side effects that may occur. Call your health care provider for medical advice about side effects.
Drug Interactions
Caffeine is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCimetidine (HCl)CinoxacinCiprofloxacinCoadministration inhibit the metabolism of caffeine thus increasing its plasma concentration and pharmacological effect.Ciprofloxacin increases caffeine AUC by 50% to over 100% and reduces its clearance upto 50%.ModerateCaffeine intake should be avoided during treatment that may increase the risk of adverse effects like tremor
insomnia
tachycardia and blood pressure.DiazepamDipyridamoleDisulfiramDue to inhibition of caffeine metabolism in liver microsomes its concentration may be increases in cardiovascular and CNS .MinorCaffeine intake should be limited while taking disulfiram.EnoxacinFenoterol Use of Fenoterol with caffeine may increase risk of hypokalemia. Frusemide or FurosemideIron SaltsLevonorgestrelMexiletineNimodipineNorfloxacinPentobarbitone (Na)Phenytoin (Na)Pipemidic AcidRiluzoleCaffeine could decrease the rate of riluzole elimination. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Pregnancy & Lactation
Pregnancy
Contraindicated in pregnancy.
Lactation
Not recommended. Consult product literature for precautions and side-effects
Storage
Tab Store at room temperature. Protect from Sunlight, Moisture and Heat.
Price Intelligence
Rs 236.29
DRAP approved maximum price · per pack of 200 · approved 01 Jul, 2025
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 200Rs 236.29
Should you consider an alternative?
Other options containing Propyphenazone, and what they are not.
These contain this ingredient plus others. They are different medicines — do not swap.
PEYONA
20mg
Rs 2,660Rs 2,660/unit
Below approved ceilingCHIESI PHARMACEUTICALS
Cafergot
+ Ergotamine
Rs 36.3
NOVARTIS
Calpol Plus
500Mg 65Mg
+ Paracetamol
Rs 52.5Rs 5.25/unit
GlaxoSmithKline PAKISTAN
Calpolplus
500mg
+ Paracetamol
Rs 55.26
GLAXOSMITHKLINE
Panadol Extra
+ Paracetamol
Rs 57Rs 5.7/unit
HALEON
Pedrol Extra
65mg
+ Paracetamol
Rs 165
Below approved ceilingNo DRAP alertsSTANLEY PHARMACEUTICALS (PVT) LTD.
Pedrolextra
+ Paracetamol
Rs 165
No DRAP alertsSTANLEY PHARMACEUTICALS (PVT) LTD.
Febrolxtra
+ Paracetamol
Rs 166
No DRAP alertsBARRETT HODGSON
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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