Yaz

Prolonged immobilization, major surgery, any surgery to the legs, or major trauma, in these situations it is advisable to discontinue COC use (in the case of elective surgery at least four weeks in advance) and not to resume until two weeks after complete remobilization, smoking, dyslipoproteinemia, hypertension, migraine, valvular heart disease, atrial fibrillation, diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, chronic inflammatory bowel disease (Crohns disease or ulcerative colitis) and sickle cell disease, hypertriglyceridemia, sustained clinically significant hypertension, hereditary angioedema, acute or chronic disturbances of liver function, varicose veins, superficial phlebitis, osteosclerosis, multiple sclerosis, epilepsy, porphyria, herpes gestationis, Sydenhams chorea, chloasma, heart rhythm/valve disorder, family history of thrombosis

heart attack or stroke

obesity, family history of breast cancer, depression, unusual severe upper abdominal complaints,