Drug Identity
Active Ingredient
Hydrocortisone
Chemical Class
Steroid
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
A01AC03, A07EA02, C05AA01, D07AA02, D07XA01, H02AB09, S01BA02, S01CB03, S02BA01
Status
Essential Medicine
What is Clozole-H?
Uses
Hydrocortisone butyrate (Locoid Lipocream, Locoid Lotion) is used to help skin conditions that respond to steroid creams. Locoid lotion c...
How It Works
Chemical Class
Steroid
Pharmacological Group
on the basis of mechanism of action and also classified in Adrenal Cortical Steroids pharmacological group
Hydrocortisone also known as Hydrocortisona, Hydrocortisone Valerate, Hydrocortisone Valerate are the derivatives of Hydrocortisone. It is of Natural origin and belongs to Steroid. It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Adrenal Cortical Steroids pharmacological group. The Molecular Weight of Hydrocortisone is 362.50. Its pKa is 13.81.
How to Take It
1
Adult · IV
100 to 500 mg — 8 hourly
2
Adult · Ophthalmic
1 % — As recommended.
As Required
3
Adult · Topical
0.1 to 2 % — 8 hourly
As Required
4
Child · Intra Muscular
5 mg/kg — 6 hourly
-
5
Child · Intra Venous
5 mg/kg — 6 hourly
-
6
Child · Opthalmic
1 % — As recommended.
As Required
Safety Alerts
Hydrocortisone is contraindicated in conditions like Ulcers, Untreated serious infections, Hypersensitivity, Idiopathic thrombocytopenic purpura, Premature infants, Systemic fungal infections
Important Warnings
Endocrine System Adverse Reactions: Reversible hypothalamic-pituitary-adrenal (HPA) axis suppression may occur, with the potential for glucocorticosteroid insufficiency
Consider periodic evaluations for HPA axis suppression if LOCOID Lotion is applied to large surface areas or used under occlusion
If HPA axis suppression is noted, reduce the application frequency, discontinue use, or switch to a lower potency corticosteroid
Systemic effects of topical corticosteroids may also include manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria
Pediatric patients may be more susceptible to systemic toxicity due to their larger skin-surface-to-body-mass ratios
Ophthalmic Adverse Reactions: Topical corticosteroids, including Locoid, may increase the risk of cataracts and glaucoma
If visual symptoms occur, consider referral to an ophthalmologist
Skin Infections: Initiate appropriate therapy if skin infections develop in the treated area
Side Effects
The most common hydrocortisone butyrate side effects are application site reactionswhich occur in more than 1% of patients Other side effects not listed may also occur in some patients. If you notice any other effectscheck with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Alsosee the warnings section.
Drug Interactions
Although certain medicines should not be used together at all
in other cases two different medicines may be used together even if an interaction might occur. In these cases
your doctor may want to change the dose
or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Storage
Inj, Oral Susp, Dental Paste, Cream, Oint Store Below 40°C. Do not Freeze. Protect from Sunlight. Suppositories Store at room temperature, Below 15°C or in refrigerator. Do not Freeze. Protect from Sunlight and Moisture. Tab Store at room temperature.
Price Intelligence
Rs 268.21
DRAP approved maximum price · per 20gm · approved 01 Jul, 2025
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper 20gmRs 268.21
Should you consider an alternative?
Other options containing Hydrocortisone, and what they are not.
Same active ingredient, a different dose. Never switch strength without your doctor or pharmacist.
Cortival
1% 10g
Rs 49.1Rs 49.1/unit
No DRAP alertsVALOR PHARMA
Hydrocortisone
10g
Rs 57.24Rs 57.24/unit
ZAFA PHARMACEUTICAL LAB
Gemcot
1%
Rs 19.01
BIO PHARMA
Hydrocortisone
10mg
Rs 21.87
Below approved ceilingXENON PHARMACEUTICALS (PVT) LTD.
Cortival
Rs 49.1
No DRAP alertsVALOR PHARMACEUTICALS
Cortival
10g
Rs 49.1
No DRAP alertsVALOR
Hydrocortisone
Rs 60.25
ZAFA PHARMACEUTICAL LABORATORIES (PVT) LTD.
Arsocortison
10mg
Rs 52.25 ceiling
No DRAP alertsArsons Pharmaceutical Industries (Pvt) Ltd
Gen-Cot
Rs 19.01 ceiling
Biogen Pharma
Cortisel
Rs 26.74 ceiling
Elite Pharma (Pvt) Ltd
Hydrovate
Rs 90.81 ceiling
No DRAP alertsPEARL PHARMACEUTICALS
Corticort
10mg
Rs 169.53 ceiling
TABROS PHARMA (PVT). LTD.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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