Drug Identity
Active Ingredient
Bisoprolol
Drug Class
Beta Blocking Agent
Chemical Class
Thiazide
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
C07AB07
Status
Essential Medicine
What is Corbis-H?
Uses
Hydrochlorothiazide is a prototype drug of thiazide diuretics. Hydrochlorothiazide is antihypertensive agent. It increases the urination ...
How It Works
Chemical Class
Thiazide
Pharmacological Group
on the basis of mechanism of action and also classified in Antihypertensive Agent, Combination pharmacological group
It is of Synthetic origin and belongs to Thiazide. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agent, Combination pharmacological group. The Molecular Weight of Hydrochlorothiazide is 297.74. Its pKa is 7.9, 9.2.
How to Take It
1
Adult · PO
25 to 100 mg — 24 hourly
As Required
2
Child · Oral
2.5 mg/kg — 12 hourly
Safety Alerts
Acute or decompensated heart failure requiring intravenous inotropes, sino-atrial block, 2nd or 3rd degree AV block (without pacemaker), severe bradycardia, uncontrolled heart failure, cardiogenic shock, severe peripheral arterial disease, hypotension, metabolic acidosis, untreated pheochromocytoma, severe asthma or COPD
Important Warnings
AV block, heart failure (avoid if un-controlled), peripheral arterial circulatory disorders (avoid if severe), Prinzmetals angina, myasthenia gravis, Ischaemic heart disease, withdraw gradually, history of bronchospasm, diabetes, hyperthyroidism, renal or hepatic impairment, psoriasis, elderly, consider withdrawal before elective surgery, anaphylaxis risk due to increased sensitivity to allergens, Always withdraw gradually over period of 1-2 weeks IV administration requires cardiac and blood pressure monitoring
Dose adjustment in renal impairment: with oral use max 50mg daily if eGFR15-35 ml/minute/1
max 25mg daily or 50 mg on alternate days if eGFR less than 15 ml/minute/1
With intravenous use max 10 mg on alternate days if eGFR15-35 ml/minute/1
10 mg every 4 days if eGFR less than 15 ml/minute/1
Side Effects
Cardiovascular effects including bradycardiapostural hypotensionincreased AV blockcardiac arrhythmiasRaynauds phenomenoncold extremitiessexual dysfunctionGI upsetsleep and CNS disturbancesskin reactionsfatigueparaesthesiaperipheral neuropathyarthralgiamyopathy
Drug Interactions
Ca+ + antagonists
antihypertensives including centrally acting agents (e.g. clonidine)
antiarrhythmics
antipsychotics
TCADs
MAOIs
fluvoxamine
barbiturates
Pregnancy & Lactation
Pregnancy
Avoid, risk cannot be ruled out.
Lactation
Contraindicated or not recommended.
Storage
Store in a well closed container, at room temperature. Protect from Moisture and Heat. Tab Store Below 40°C. Protect from Sunlight and Heat.
Price Intelligence
Rs 262.17
DRAP approved maximum price · per pack of 20 · approved 11 Aug, 2025
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 20Rs 262.17
Should you consider an alternative?
Other options containing Bisoprolol, and what they are not.
Identical active ingredient at the same strength. Cheapest per unit first.
Valvozidplus
5mg
Rs 138.74
PACIFIC PHARMACEUTICALS LTD.
Sopral Plus
5mg
Rs 193.07 ceiling
No DRAP alertsBRYON PHARMACEUTICALS (PVT) LTD.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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