Drug Identity
Active Ingredient
Bupropion
Chemical Class
Amino propanone
ATC Code
N06AX12
Status
Essential Medicine
What is Deprion Sr?
Uses
Bupropion (HCl) is an antidepressant chemically unrelated to other classes of antidepressants. It weakly inhibits the neuronal reuptake o...
How It Works
Chemical Class
Amino propanone
It is of Synthetic origin and belongs to Amino propanone. The Molecular Weight of Bupropion (HCl) is 276.20. Its pKa is 7.9.
How to Take It
1
Adult · PO
150 mg — 24 hourly
Initially for 6 days.Then 150 mg BD. Max. daily dose 300 mg.
Safety Alerts
Bupropion (HCl) is contraindicated in conditions like Brain tumors, Pregnancy, Seizures, Head injury, Breast feeding
Important Warnings
It should be used with extreme caution in patient with a history of seizure disorders, with care in bipolar disorder or psychoses, patient with a recent history of myocardial infarction or unstable heart disease (measure blood-pressure before and during treatment
hepatic (avoid in severe hepatic cirrhosis)
renal impairment
Side Effects
The severe or irreversible adverse effects of Bupropion (HCl)which give rise to further complications include EosinophiliaNeuropsychiatric disturbances. Bupropion (HCl) produces potentially life-threatening effects which include Seizures. which are responsible for the discontinuation of Bupropion (HCl) therapy. The signs and symptoms that are produced after the acute overdosage of Bupropion (HCl) include TachycardiaSeizuresHallucinationsCardiovascular collapseLoss of consciousness. The symptomatic adverse reactions produced by Bupropion (HCl) are more or less tolerable and if they become severethey can be treated symptomaticallythese include HeadacheNauseaVomitingConstipationInsomniaDry mouthWeight Loss
Drug Interactions
Bupropion (HCl) is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepinePlasma concentration of Bupropion reduced by Carbamazepine.Cimetidine (HCl)Diphenyl PyralineFluoxetine (HCl)FluspirileneLikely interaction of FLUSPIRILENE increasing the CONVULSANT effect of BUPROPION. May need to avoid combination.ModerateIprindoleLikely interaction of IPRINDOLE increasing the CONVULSANT effect of BUPROPION. Moderate risk.ModerateMay need to avoid combination.Iproniazid PhosphateLikely interaction of IPRONIAZID increasing the CONVULSANT effect of BUPROPION. ModerateMay need to avoid combination.LevodopaIncreased risk of side effects when Bupropion given with Levodopa.LithiumLofepramine (HCl)Likely interaction of LOFEPRAMINE increasing the CONVULSANT effect of BUPROPION. ModerateMay need to avoid combinationMoclobemideADVICE: Avoid concomitant use with Moclobemide.MajorOpiumConcurrent use may increase a dose-related risk of seizures. OxymorphoneThe use of bupropion is associated with a dose-related risk of seizures. The estimated incidence of seizures is approximately 0.1% at dosages up to 300 mg/day and 0.4% at dosages between 300 to 450 mg/day
but increases almost tenfold between 450 mg and 600 mg/day. The risk may also be increased during coadministration with selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics)
monoamine oxidase inhibitors
neuroleptic agents
central nervous system stimulants
opioids
tricyclic antidepressants
Storage
Tab Store at room temperature, Between 15°C-25°C. Protect from Sunlight and Moisture.
Price Intelligence
Rs 282.2
DVAGO observed price · per pack of 10 · as of 30 July 2026
Rs 28.22 per unit
~9% below the approved ceiling, per unit
Prices across sources
DRAPper pack of 10Rs 311.2
DVAGOper pack of 10Rs 282.2
Should you consider an alternative?
Other options containing Bupropion, and what they are not.You pay Rs 11 more than the cheapest equivalent
Identical active ingredient at the same strength. Cheapest per unit first.
Zylexx Sr
150Mg
Rs 271Rs 27.1/unit
Lowest price per unitAraf Pharmaceuticals
Butrin Xl
150Mg
Rs 285.6Rs 28.56/unit
Below approved ceilingNo DRAP alertsGenetics Pharmaceuticals Pvt Ltd
Buproneach
150mg
Rs 345.22
No DRAP alertsCCL Pharmaceuticals (Pvt.) Ltd.
Zylexx
150mg
Rs 393
No DRAP alertsARAF
Wellben
150mg
Rs 583.82
ATCO LABORATORIES LIMITED
Zyban
150mg
Rs 847.18
No DRAP alertsSeraph Pharmaceutical DML: 000860
Smokik SR
150mg
Rs 612.15 ceiling
HILTON PHARMA (PVT) LIMITED
Bupress XL
150mg
Rs 193.89 ceiling
No DRAP alertsNAVEGAL LABORATORIES
Ropion SR
150mg
Rs 683.6 ceiling
No DRAP alertsThe Searle Company Limited
Xaslexx
150mg
Rs 635.47 ceiling
Mass Pharma (Pvt) Ltd.
Budep
150mg
Rs 666.85 ceiling
No DRAP alertsPharmatec Pakistan (Pvt.) Limited
Bupron
150mg
Rs 345.22 ceiling
No DRAP alertsCCL Pharmaceuticals (Pvt.) Ltd.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
Often Bought Together
Dipof — Dipof Capsules 3Mg/25Mg (1 Box = 2 Strips) (1 Strip = 10 Capsules) Rs 109.7Vornue — Vornue Tablets 10Mg (1 Box = 2 Strips) (1 Strip = 7 Tablets)Rs 416.08Olanzaget — Olanzaget Tablets 6Mg/25Mg (1 Box = 2 Strips) (1 Strip = 7 Tablets)Rs 205.17Talopex — Talopex Tablets 5Mg (1 Box = 1 Strip)(1 Strip = 14 Tablets)Rs 256.62Serloft — Serloft Tablets 50Mg (1 Strip = 10 Tablets)Rs 185
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