Drug Identity
Active Ingredient
Bupropion
Chemical Class
Amino propanone
ATC Code
N06AX12
Status
Essential Medicine
What is Deprion SR?
Uses
Bupropion (HCl) is an antidepressant chemically unrelated to other classes of antidepressants. It weakly inhibits the neuronal reuptake o...
How It Works
Chemical Class
Amino propanone
It is of Synthetic origin and belongs to Amino propanone. The Molecular Weight of Bupropion (HCl) is 276.20. Its pKa is 7.9.
How to Take It
1
Adult · PO
150 mg — 24 hourly
Initially for 6 days.Then 150 mg BD. Max. daily dose 300 mg.
Safety Alerts
Bupropion (HCl) is contraindicated in conditions like Brain tumors, Pregnancy, Seizures, Head injury, Breast feeding
Important Warnings
It should be used with extreme caution in patient with a history of seizure disorders, with care in bipolar disorder or psychoses, patient with a recent history of myocardial infarction or unstable heart disease (measure blood-pressure before and during treatment
hepatic (avoid in severe hepatic cirrhosis)
renal impairment
Side Effects
The severe or irreversible adverse effects of Bupropion (HCl)which give rise to further complications include EosinophiliaNeuropsychiatric disturbances. Bupropion (HCl) produces potentially life-threatening effects which include Seizures. which are responsible for the discontinuation of Bupropion (HCl) therapy. The signs and symptoms that are produced after the acute overdosage of Bupropion (HCl) include TachycardiaSeizuresHallucinationsCardiovascular collapseLoss of consciousness. The symptomatic adverse reactions produced by Bupropion (HCl) are more or less tolerable and if they become severethey can be treated symptomaticallythese include HeadacheNauseaVomitingConstipationInsomniaDry mouthWeight Loss
Drug Interactions
Bupropion (HCl) is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepinePlasma concentration of Bupropion reduced by Carbamazepine.Cimetidine (HCl)Diphenyl PyralineFluoxetine (HCl)FluspirileneLikely interaction of FLUSPIRILENE increasing the CONVULSANT effect of BUPROPION. May need to avoid combination.ModerateIprindoleLikely interaction of IPRINDOLE increasing the CONVULSANT effect of BUPROPION. Moderate risk.ModerateMay need to avoid combination.Iproniazid PhosphateLikely interaction of IPRONIAZID increasing the CONVULSANT effect of BUPROPION. ModerateMay need to avoid combination.LevodopaIncreased risk of side effects when Bupropion given with Levodopa.LithiumLofepramine (HCl)Likely interaction of LOFEPRAMINE increasing the CONVULSANT effect of BUPROPION. ModerateMay need to avoid combinationMoclobemideADVICE: Avoid concomitant use with Moclobemide.MajorOpiumConcurrent use may increase a dose-related risk of seizures. OxymorphoneThe use of bupropion is associated with a dose-related risk of seizures. The estimated incidence of seizures is approximately 0.1% at dosages up to 300 mg/day and 0.4% at dosages between 300 to 450 mg/day
but increases almost tenfold between 450 mg and 600 mg/day. The risk may also be increased during coadministration with selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics)
monoamine oxidase inhibitors
neuroleptic agents
central nervous system stimulants
opioids
tricyclic antidepressants
Storage
Tab Store at room temperature, Between 15°C-25°C. Protect from Sunlight and Moisture.
Price Intelligence
Rs 2,607.37
DRAP approved maximum price · per pack of 30 · approved 23 Jul, 2026
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 30Rs 2,607.37
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Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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