Drug Identity
Active Ingredient
Glibenclamide
Drug Class
Diabetes
Chemical Class
Sulphonylurea
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
A10BB01
Status
Essential Medicine
What is Glimet?
Uses
Glibenclamide is a oral hypoglycemic agent. Glibenclamide is used in the treatment of non-insulin dependent diabetes. Glibenclamide is us...
How It Works
Chemical Class
Sulphonylurea
Pharmacological Group
on the basis of mechanism of action and also classified in Drugs Affecting Glucose Metabolism and Antidiabetic Agent, Sulfonylurea pharmacological group
Glibenclamide also known as Glyburide. It is of Synthetic origin and belongs to Sulphonylurea. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Drugs Affecting Glucose Metabolism and Antidiabetic Agent, Sulfonylurea pharmacological group. The Molecular Weight of Glibenclamide is 494.00. Its pKa is 5.3.
How to Take It
1
Adult · PO
2.5 mg — 24 hourly
Dose may be increased by 2.5 mg.
2
Child
Not recommended in this age group
Safety Alerts
Glibenclamide is contraindicated in conditions like Renal failure,Liver diseases,Diabetic coma,Impaired renal function,Insulin dependent diabetes mellitus
Important Warnings
During treatment with glibenclamide, compliance to diet and regular tablet intake are of utmost importance to preserve the efficacy of treatment and to avoid unwanted changes in the blood sugar levels
Hypoglycemic reactions may provoked by overdosage of glibenclamide, interacting drugs , dietary errors (omitting meals), the signs of it being headache, irritability, restlessness, profuse sweating, insomnia, tremor, impairment of performance and alertness, such hypoglycemic episodes are nearly always promptly relieved by the intake of sugar
Side Effects
The severe or irreversible adverse effects of Glibenclamidewhich give rise to further complications include ThrombocytopeniaCholestatic jaundiceAplastic anemiaHemolytic anemiaLeucopeniaAgranulocytosisPancytopenia. Glibenclamide produces potentially life-threatening effects which include Hypersensitivity reactionsRenal failureHypoglycemiaPneumonia. which are responsible for the discontinuation of Glibenclamide therapy. The signs and symptoms that are produced after the acute overdosage of Glibenclamide include ComaHypoglycemiaCerebral damage.The symptomatic adverse reactions produced by Glibenclamide are more or less tolerable and if they become severethey can be treated symptomaticallythese include Nausea
Drug Interactions
Glibenclamide is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholBosentanPlasma concentration of both drugs reduced when Bosentan given with Glibenclamide
avoid concomitant use.MajorDiazoxideDiazoxide antagonises hypoglycaemic effect of antidiabetics.LinagliptinLinagliptin increases AUC and Cmax of Glibencamide by 14%LornoxicamMay increase the hypoglycaemic effect of sulphonylurea.Metformin (HCl)MethylprednisoloneSteroids (e.g Methylprednisolone) induced hyperglycemia may partially antagonize the effect of hypoglycemic drugs (e.g Glibenclaimide)Propranolol (HCl)Tincture MyrrhTincture Myrrh may increase the level of suger in blood if taking myrrh by mouth & may interfere with the effectiveness of medications used for the treatment of diabetes.Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Store Below 20°C. Tab Store in a well closed container, Below 40°C.
Price Intelligence
Rs 61.8
DVAGO observed price · as of 30 July 2026
No approved ceiling matched to this exact pack and strength.
Prices across sources
DVAGORs 61.8
Should you consider an alternative?
Other options containing Glibenclamide, and what they are not.
Same active ingredient, a different dose. Never switch strength without your doctor or pharmacist.
Glucomet
500mg
Rs 38Rs 3.8/unit
No DRAP alertsPHARMATEC PAKISTAN (PVT) LTD.
Daonil
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Rs 313.8Rs 5.23/unit
SANOFI-AVENTIS PAKISTAN LTD.
Glucovance
250Mg
Rs 166.2Rs 5.54/unit
No DRAP alertsMartin Dow
Glucomet Plus
500mg
Rs 66.3Rs 6.63/unit
No DRAP alertsPHARMATEC PAKISTAN (PVT) LTD.
Glucovance
500Mg
Rs 140.1Rs 9.34/unit
No DRAP alertsMartin Dow
Glucovance
500Mg
Rs 291.6Rs 9.72/unit
No DRAP alertsMartin Dow
Daonilm
5mg
Rs 120
SANOFI AVENTIS (PAKISTAN) LTD.
Glimetica
250mg
Rs 105.86 ceiling
Mega Pharmaceuticals limited
Glimetica
500mg
Rs 131.16 ceiling
Mega Pharmaceuticals limited
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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