Rifa

Rifampicin is known to interact with other drugs

the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAbacavirRifampicin reduces plasma concentration of abacavir. Adefovir DipivoxilAfatinibmay decrease the level of afatinibuse alternative or increased afatinib daily doseAluminium Hydroxide and OxideAminophyllineAmprenavirPlasma concentration of Amprenavir significantly reduced by Rifampicin. ADVICE: Avoid concomitant use.MajorArtesunateConcurrent use may decrease artesunate serum concentrations. Avoid co-administration if possible. Monitor closely for therapeutic efficacy. Artesunate dose may need to be increased with co-administration.AtovaquonePlasma concentration of Atovaquonone reduced by rifampicin (possible therapeutic failure of atovaquone). Beclomethasone (Dipropionate)Rifampicin reduce the activity of corticosteroids by accelerating their metabolismBetamethasoneRifampicin reduce activity of corticosteroids by accelerating metabolism of betamethaosoneDose reduction is necessaryBisoprolol (Fumarate)Metabolism of Bisoprolol accelerated by Rifampicin (plasma concentration significantly reduced)ModerateBromazepamCalcifediolCanagliflozinco administration may decrease efficacy of canagliflozinincreaes the dose to 300mg once dailyCarvedilolCelecoxibChloramphenicolRifampicin causes subtherapeutic concentration of chloramphenicol.ChloramphenicolChlorpropamideCholecalciferolCiprofloxacinRifampin induces the metabolism of ciprofloxacin.ClofazimineClofazimineClofibrateCorticotropinCortisone (Acetate)Co-TrimoxazoleCyclosporin ACyclosporin ADabigatranreduces exposure to dabigatran It should generally be avoided.DabrafenibStrong CYP3A4 inducers may decrease levels of dabrafenibconsider alternate therapyDapsoneDapsoneDesogestrelDesonideDexamethasoneDiazepamDienoestrolDigitoxinDigitoxinDigoxinDiltiazem (HCl)DisopyramideDisopyramideDisulfiramDolutegravirRifampin (600 mg) decreases dolutegravir AUC and Cmin the dolutegravir dosage should be increasedDoxycyclineDydrogesteroneEnalapril (Maleate)ErlotinibDecreased levels/effect of erlotinibEstazolamEstradiol (Valerate)Estradiol.EthinyloestradiolEthionamideHepatitis occurs with jaundice mostly when both drugs are co administeredEthynodiol (Diacetate)FelodipineFluconazoleRifampicin induce metabolism of fluconazoleFludrocortisone (Acetate)FlunisolideFluprednisoloneFluticasone PropionateFosphenytoinGallopamilGestodeneGestrinoneGliclazideHaloperidolHexobarbitone (Na)HydrocortisoneIloprostImidaprilRifampicin reduces plasma concentration of active metabolite of Imidapril (reduced antihypertensive effect)IsoniazidIsoniazidIsradipineItraconazoleKetoconazoleKetoconazoleLercanidipine (HCl)LevonorgestrelLinagliptinRifampicin decreases AUC and Cmax of Linagliptin by 39.6% and 43.8% respectivelyLurasidoneRifampicin is a strong CYP3A4 inducer

decreases Cmax and AUC of LurasidoneContraindicatedLynoestrenolMacitentanrifampin significantly reduce macitentan exposureConcomitant use of macitentan with strong CYP3A4 inducers should be avoidedMegestrol (Acetate)MeprobamateMestranolMethadoneMethylprednisoloneMexiletineMontelukastRifampicin may have the same effect as montelukast. Therefore

the dose of montelukast may need to be reduced when given concurrently with rifampicin. Employ appropriate clinical monitoring.MycophenolateNelfinavirNevirapineNilotinibsystemic exposure to nilotinib was decreased approximately 80%.NorethisteroneNorgestimateOndansetron (HCl)By concurrent use the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However

on the basis of available data

no dosage adjustment for ondansetron is recommended for patients on these drugs.No dosage adjustment for ondansetron is recommended for patients on these drugs.Oxtriphylline (Choline Theophyllinate)Para-Amino Salicylic AcidPitavastatinRifampin significantly increased pitavastatin exposure. In patients taking rifampin

a dose of PIVASTATIN 2 mg once daily should not be exceededPrajmalium Bitartaraterifampicin increases hepatic metabolism of prajmalium bitartarate.Prednisolone and PrednisoneRifampicin accelerate metabolism of prednisolone and prednisonePrednisolone TebutateRifampicin decrease activity of Prednisolone Tebutate.ProbenecidProgesteronePropafenone (HCl)ProthionamideQuinestrolRifampicin and other liver enzyme inducers e.g griseofulvin enhances the metabolism of quinestrol.QuinidineQuinidineQuinineRanolazineRifampin (600 mg once daily) decreases the plasma concentration of ranolazine (1000 mg twice daily) by approximately 95% by induction of CYP3A and

probably