Drug Identity
Active Ingredient
Amitriptyline
Drug Class
Neuro
Chemical Class
Dibenzocycloheptadiene
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
N06AA09
Status
Essential Medicine
What is AMYLINE?
Uses
Amitriptyline (HCl) is a prototype drug of tricyclic antidepressants. It has characteristic three ring nucleus. Tricyclic antidepressant ...
How It Works
Chemical Class
Dibenzocycloheptadiene
Pharmacological Group
on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant pharmacological group
Amitriptyline is the derivative of Amitriptyline (HCl). It is of Synthetic origin and belongs to Dibenzocycloheptadiene. It belongs to Adenosine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant pharmacological group.The Molecular Weight of Amitriptyline (HCl) is 313.90. Its pKa is 9.4.
How to Take It
1
Adult · IM
0.285 to 0.429 mg/ kg — 6 hourly
Initial
2
Adult · IM
0.714 to 2.143 mg/ kg — 24 hourly
Maintenance for 6 Months
3
Adult · PO
50 to 100 mg — 24 hourly
At bedtime, increased gradually to 150 mg/day.
4
Child · Oral
0.4 to 0.8 mg/kg — 24 hourly
Recommended for 5-12 yrs Children
Safety Alerts
Arrhythmias, acute porphyrias, during manic phase of bipolar disorder, heart block, immediate recovery period after myocardial infarction, severe liver disorder
Important Warnings
Cardiovascular disease (risk of sudden death), hepatic impairment (avoid if severe), diabetes, epilepsy, history of bipolar disorder, history of psychosis or mania, chronic constipation, hyperthyroidism, increased intra-ocular pressure, patients with risk of suicide, phaeochromocytoma, prostatic hypertrophy, susceptibility to angle-closure glaucoma, urinary retention, withdraw gradually
Side Effects
Agitationanorexiafatiguehypertensionmydriasisoedemapalpitationrestlessnessstomatitisblurred visionconfusionconstipationconvulsionsdelusionsdizziness
Drug Interactions
With or within 14 days of MAOIs. Other antide-pressants
St. Johns Wort
tramadol
drugs that prolong the QT interval (e.g. antiarrhythmics)
moxifloxacin
anticonvulsants
diltiazem
verapamil
Pregnancy & Lactation
Pregnancy
Avoid unless potential benefit outweighs risk
Lactation
Contraindicated, avoid
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Price Intelligence
Rs 153
Servaid observed price · as of 30 July 2026
Prices across sources
DRAPper pack of 100Rs 231.03
ServaidRs 153
Should you consider an alternative?
Other options containing Amitriptyline, and what they are not.
Identical active ingredient at the same strength. Cheapest per unit first.
Ready
25mg
Rs 140.83 ceiling
No DRAP alertsXENON PHARMACEUTICALS (PVT) LTD.
Amitin
25mg
Rs 1,442.14 ceiling
Glitz Pharma
Amotrip
25mg
Rs 189.01 ceiling
No DRAP alertsPharmedic Pharmaceuticals Industries (Pvt.) Ltd.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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