Drug Identity
Active Ingredient
Amitriptyline
Chemical Class
Dibenzocycloheptadiene
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
N06AA09
Status
Essential Medicine
What is Ready?
Uses
Amitriptyline (HCl) is a prototype drug of tricyclic antidepressants. It has characteristic three ring nucleus. Tricyclic antidepressant ...
How It Works
Chemical Class
Dibenzocycloheptadiene
Pharmacological Group
on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant pharmacological group
Amitriptyline is the derivative of Amitriptyline (HCl). It is of Synthetic origin and belongs to Dibenzocycloheptadiene. It belongs to Adenosine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant pharmacological group.The Molecular Weight of Amitriptyline (HCl) is 313.90. Its pKa is 9.4.
How to Take It
1
Adult · IM
0.285 to 0.429 mg/ kg — 6 hourly
Initial
2
Adult · IM
0.714 to 2.143 mg/ kg — 24 hourly
Maintenance for 6 Months
3
Adult · PO
50 to 100 mg — 24 hourly
At bedtime, increased gradually to 150 mg/day.
4
Child · Oral
0.4 to 0.8 mg/kg — 24 hourly
Recommended for 5-12 yrs Children
Safety Alerts
Amitriptyline (HCl) is contraindicated in conditions like Glaucoma, Acute recovery phase following Myocardial infarction, Prostatic hypertrophy
Important Warnings
Amitriptyline (HCl) should be used with caution in patients with cardiac disease and pre-existing hematological disorders
It is classified as a pregnancy category C drug
No complete or well-controlled studies have been done
Use during pregnancy should be avoided unless the potential benefits outweigh the possible risks to the fetus
Abrupt discontinuation should be avoided because it could precipitate symptoms of cholinergic rebound such as nausea, vomiting or diarrhea
It should be used with caution in patients with history of alcoholism or who may use sedative medicines because the depressant effect on CNS can be potentiated
Avoid Concurrent use with Cisapride
Side Effects
The severe or irreversible adverse effects of Amitriptyline (HCl)which give rise to further complications include Postural hypotensionTachycardiaCardiac arrhythmiasConduction disturbancesCongestive heart failure.Amitriptyline (HCl) produces potentially life-threatening effects which include AgranulocytosisThrombocytopenia. which are responsible for the discontinuation of Amitriptyline (HCl) therapy.The signs and symptoms that are produced after the acute over dosage of Amitriptyline (HCl) include HypotensionCardiac arrhythmiasComaSeizuresBlurred visionDry mouthUrinary retentionHypothermiaMetabolic acidosis
Drug Interactions
Amitriptyline (HCl) is known to interact with other drugs
the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcrosoxacinAdrenalineAlcoholAntazolineIncreased antimuscarinic and sedative effects when antihistamines (e.g Antazoline) given with tricyclic antidepressants (e.g Amitriptyline)Apraclonidine (HCl)Avoid concomitant use.AstemizoleBethanidine (Sulphate)Bretylium (Tosylate)CarbamazepineCarbamazepine accelerates metabolism of tricyclics (e.g Amitriptyline)
reduced plasma concentration by induction of CYP450 enzymes and reduced effects. ModerateTolerance
patient response
seizure control and monitoring of serum concentration should be done.Cimetidine (HCl)CisaprideCisapride can cause ventricular arrhythmia due to prolong QT interval when given with Amitriptyline.MajorThis combination is contraindicated.Clonidine (HCl)Debrisoquine (Sulphate)DisopyramideDisulfiramEnfluraneEnfluraneErgotamine (Tartrate)reports of serotonin syndrome in patients recieving ergotamine with amitriptyline
imipramine
paroxetine
or sertralineFenfluramine (HCl)FluconazoleFluconazole inhibit CYP450 3A4 isoenzyme which decrease Amitriptyline clearance leads to CNS toxicity and prolong QT interval. ModerateAdjust amitriptyline dose and monitor its serum levels.Fluvoxamine (Maleate)Amitriptyline metabolism is decrease while plasma concentration is increased by flovoxamine which inhibit multiple hepatic microsomal enzymes.MajorCoadministration of these two drugs are avoided.FurazolidoneGuanethidineHuman InsulinIndacaterol prolong the QTc interval should be monitored closely.Insulin LisproIproniazid PhosphateInfrequent reports of AMITRIPTYLINE increasing the SEROTONERGIC effect of IPRONIAZID. Potential risk. IsoproterenolLevodopaLevodopa serum concentration is reduced by amitriptyline due to slow gastric emptying and increase gastric degradation.Patient monitor for altered safety and efficacy.LoprazolamTheoretical potential for LOPRAZOLAM increasing the SEDATIVE effect of AMITRIPTYLINE. ModerateMazindolNabiloneConcurrent use may increase the efficacy of nabilone.Concurrent use should be avoided
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Price Intelligence
Rs 140.83
DRAP approved maximum price · per pack of 100 · approved 30 Jun, 2026
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 100Rs 140.83
Should you consider an alternative?
Other options containing Amitriptyline, and what they are not.
Identical active ingredient at the same strength. Cheapest per unit first.
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Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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