Drug Identity
Active Ingredient
Neostigmine
Chemical Class
Quaternary Ammonium
Pharmacological Group
on the basis of mechanism of action and also cl...
ATC Code
N07AA01, S01EB06
Status
Essential Medicine
What is Netigmine?
Uses
Neostigmine is used to reverse the effects of anesthesia medications used during surgery . Neostigmine may also be used for purposes not ...
How It Works
Chemical Class
Quaternary Ammonium
Pharmacological Group
on the basis of mechanism of action and also classified in Antidotes and Cholinergic Agonist pharmacological group
Neostigmine (Methylsulphate),are the derivatives of Neostigmine. It is of Synthetic origin and belongs to Quaternary Ammonium. It belongs to Cholinesterase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidotes and Cholinergic Agonist pharmacological group. The Molecular Weight of Neostigmine is 223.30. It is weakly acidic drug, 4.98% solution of the drug is isotonic and Its pKa is 12.0.
How to Take It
1
Adult · IM
0.02 mg/ kg — As recommended.
For diagnosis of myasthenia gravis
2
Adult · IV, IM, SC
0.5 to 2.5 mg — As recommended.
Additional doses depend upon the patient response. Max. 10mg/day
3
Adult · PO
15 mg — 4 hourly
Max. 375mg/day
4
Child · Intra Venous
50 to 0 ug/kg — As recommended.
To severe neuromuscular blockade.
5
Child · Oral
200 to 0 mg/kg — 6 hourly
For Myasthenia grains.
Safety Alerts
You should not be treated with neostigmine if you are allergic to it, or if you have: a bladder obstruction or other urination problems
a blockage in your digestive tract (stomach or intestines)
or a serious disorder called peritonitis (inflammation of the membrane lining the organs inside your abdomen)
Tell your doctor if you have ever had: coronary artery disease (clogged arteries)
a heart rhythm disorder
Important Warnings
You should not be treated with neostigmine if you have a bladder or bowel obstruction , or a serious disorder called peritonitis (inflammation of the membrane lining the organs inside your abdomen)
Side Effects
Get emergency medical help if you have signs of an allergic reaction : hivesdifficult breathingswelling of your facelipstongueor throat. Tell your caregivers right away if you have muscle weakness as you wake up from surgery. Common side effects of neostigmine may include: nauseavomitingor slow heartbeats. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Drug Interactions
Other drugs may affect neostigmine
including prescription and over-the-counter medicines
vitamins
and herbal products . Tell your doctor about all your current medicines and any medicine you start or stop using.
Storage
Inj Store Below 40°C. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, Below 40°C.
Price Intelligence
Rs 109.71
DRAP approved maximum price · per pack of 5 · approved 27 Jul, 2026
No retail price observed for this pack. Retailers may not exceed the approved maximum.
Prices across sources
DRAPper pack of 5Rs 109.71
Should you consider an alternative?
Other options containing Neostigmine, and what they are not.
These contain this ingredient plus others. They are different medicines — do not swap.
Neostig
2.5mg
+ Neostigmine Methylsulphate
Rs 82.07
No DRAP alertsSIZA INTERNATIONAL (PVT) LTD.
Glycosting
+ Glycopyrrolate
Rs 614.6
BAJWA
Neostign
1ml
+ Neostigmine Methylsulphate
Rs 718.33
Bajwa Pharmaceuticals (Pvt.) Ltd.
Neostig
0.5mg
+ Neostigmine Methylsulphate
Rs 1,079.84
No DRAP alertsSIZA INTERNATIONAL (PVT) LTD.
Neopyrolate
1ml
+ Glycopyrrolate
Rs 1,136.6
BROOKES
Nestigin
0.5mg/ml
+ Neostigmine Methylsulphate
Rs 2,059.06
ELITE PHARMA
Nestigin
0.5mg
+ Neostigmine Methylsulphate
Rs 2,059.06 ceiling
Elite Pharma (Pvt) Ltd
Neostig-N
2.5mg
+ Neostigmine Methylsulphate
Rs 718.33 ceiling
Bajwa Pharmaceuticals (Pvt.) Ltd.
Ordered by lowest price per unit where a pack size is known, then by price. Order is never affected by sponsorship. Not medical advice — confirm any change with your pharmacist or doctor.
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